302例胃癌患者舌下络脉的临床观察

Clinical Observation of Sublingual Collaterals in 302 Patients with Gastric Cancer

[目的]探讨胃癌患者的舌下络脉特征。[方法]对302例胃癌患者舌下络脉特征进行观察和分析,探讨其与患者临床病理特征间及肿瘤标志物间的关系。[结果]舌下络脉分级与胃癌患者一般临床信息差异无统计学意义;胃癌晚期患者舌下络脉分级水平明显高于胃癌早期患者,差异有统计学意义(P<0.01);与胃癌早期患者相比,胃癌晚期患者舌下络脉长度、宽度、形态、颜色、瘀点重度程度患者增多,舌下络脉宽度、形态、瘀点正常程度患者减少,差异有统计学意义(P<0.05)。舌下络脉分级与胃癌分化程度、病理类型、肿瘤位置分布无明显相关性;肿瘤≥5 cm患者舌下络脉2级为主,与肿瘤<5 cm相比差异有统计学意义(P<0.05)。肿瘤标志物CA50、CA199高水平者以舌下络脉2级为主,与正常水平者相比差异显著(P<0.05)。[结论]观察舌下络脉的变化对胃癌的临床分期、肿瘤大小、肿瘤标志物以及中医辨证及预后有一定意义。

[Objective]To investigate the characteristics of sublingual collaterals in patients with gastric cancer.[Methods]The characteristics of sublingual collaterals in 302 patients with gastric cancer were observed and analyzed,and the relationship of sublingual collaterals with clinicopathological features and tumor markers was discussed.[Results]There was no significant difference between sublingual collateral classification and general clinical information of gastric cancer patients.The level of sublingual collateral classification in patients with advanced gastric cancer was significantly higher than that in patients with early gastric cancer(P<0.01).Compared with patients with early gastric cancer,patients with advanced gastric cancer had more sublingual collaterals in terms of length,width,shape,color and severity of petechiae,while the proportion of patients with normal sublingual collaterals decreased(P<0.05).The sublingual collateral classification was not correlated with the differentiation degree,pathological type,tumor location and distribution of gastric cancer.The sublingual collaterals of patients with tumor≥5 cm were mainly grade 2,which was significantly different with those with tumor<5 cm(P<0.05).The sublingual collaterals in patients with high levels of CA50 and CA199 were mainly in grade 2,which was significantly different with those with low tumor marker levels(P<0.05).[Conclusion]Observing the changes of sublingual collaterals is of certain significance in the clinical stage,tumor size,tumor markers,TCM syndrome differentiation and prognosis of gastric cancer patients.