载脂蛋白E基因型与血管性认知损害

Apolipoprotein E genotypes and vascular cognitive impairment

血管性认知损害是目前唯一可干预的认知损害性疾病。近年来,有关其遗传因素的研究受到重视。其中,载脂蛋白E(apolipoprotein E,ApoE)及其基因型与脂质代谢、β-淀粉样蛋白聚集和沉积、脑结构和功能改变有着紧密的联系,且与痴呆发病密切相关。文章对ApoE及其基因型影响认知功能的一些可能机制进行了探讨,以期为血管性认知损害患者的认知功能管理提供参考。

Vascular cognitive impairment is the only cognitive impairment disease that can be intervened at present.In recent years,the research on its genetic factors has attracted much attention.Among them,apolipoprotein E(ApoE)and its genotypes are closely associated with lipid metabolism,β-amyloid aggregation and deposition,the changes of brain structure and function,and are closely correlated with the pathogenesis of dementia.This article discusses some possible mechanisms of ApoE and its genotypes affecting cognitive function,in order to provide reference for the management of cognitive function in patients with vascular cognitive impairment.