丁苯酞联合早期康复训练对老年急性脑梗死脑循环改善及预后效果分析

Analysis of butyphthalide combined with early rehabilitation training on cerebralcirculation and prognosis in elderly patients with acute cerebral infarction

目的探讨丁苯酞联合早期康复训练对老年急性脑梗死脑循环改善及预后的效果。方法选取2019年1月-2020年9月中国航天科工集团七三一医院神经内科收治并追踪观察的老年急性脑梗死患者10例,随机分为观察组和对照组各35例,均给予常规治疗后,对照组给予早期康复训练,观察组在对照组的基础上给予丁苯酞注射液治疗。比较两组患者治疗前后的脑血流速度、脑血管储备能力以及美国国立卫生研究院脑卒中量表(NIHSS)、Barthel指数(BI)评分和治疗预后效果。结果观察组治.疗后MCA、ACA、PCA平均流速增加,较对照组增加更为显著[(68.26±9.43)cm/s vs(57.12±6.08)cm/s,(58.17±5.43)cm/s vs(52.25±6.12)cm/s,(42.32±9.04)cm/s vs(37.06±6.11)cm/s,P<0.05)]。治疗2周后,观察组有21例建立侧支循环,对照组有10例建立侧支循环,观察组侧支循环建立比例高于对照组(60.00‰vs28.57%,P<0.05)。两组治疗后CVR均较治疗前有所增高,PI均较治疗前有所下降,观察组CVR、PI改善较对照组明显[(40.16±5.43)%vs(28.02±6.51)%,(0.71±0.21)vs(0.91±0.14),P<0.05]。观察组治疗总有效率为94.29%,明显高于对照组的71.14%(P<0.05);治疗后两组NIHSS评分降低、BI指数增高,且观察组较对照组改善更显著[(3.64±4.11)分vs(8.26±3.28)分,(70.38±10.36)分vs(60.47±11.23)分,P<0.05]。结论丁苯酞结合早期康复训练应用于老年急性脑梗死治疗效果显著,可促进侧支循环建立、改善脑血流,有效改善神经功能缺损及日常生活能力,提高治疗效果。

Objective To investigale the effct of butylphthalide combined with early rehabilitation training in elderly patients withacute cerebral infarction.Methods A total of 70 patients with cerebral infartion who were treated in our hospital from January 2019 toSeptember 2020 were enrolled in the study,who were divided into study group and control group,with 35 cases in each group.Both weregiven conventional treatment.The control group was given early rehabilitation training.The study group was given butylphthalide injectionon the basis of the control group.Compare the therapeutic effcts of the two groups,the levels of cerebral blood flow,cerebrovascularreserve and the establishment of collateral compensatory vessels,and National Institute of Health Stroke Seale(ANIHSS)Barthel Index(BDscore.Results The total effective rate of treatment in the study group was 94.29%,which was significantly higher than 77.14%in thecontrol group(P<0.05)cerebral blood flow increased in the two groups after treatment(P<0.05).After treatment,the NIHSS scores ofthe two groups decreased(P<0.05),and the study group was significantly lower than the control group(P<0.05),the Bl scores of the twogroups increased(P<0.05),and the study group was higher than the control group(P<0.05)Conclusion Butyliphthalein combined withearly rehabilitation training has significant therapeutic efifets in elderly patients with acute cerebral infarction.It can effecively improveneurological deficits,daily living ability,and exercise capacity.