阴虚证古方用药规律研究

Research on the rule of ancient prescriptions of yin deficiency syndrome

目的采用数据挖掘方法分析古代方剂中治疗阴虚证方剂的用药规律,为临床以阴虚为基础证候疾病的辨治施药提供参考。方法检索中国中医科学院中医药信息研究所开发的"已上市经典名方数据库",筛选治疗阴虚证的处方,采用古今医案云平台V2.2.3统计用药频次、药物性味归经,并进行层次聚类分析寻找核心组方。采用MATLAB进行中药关联规则分析药物配伍规律。采用Pajek645.13进行复杂网络分析找出核心中药。结果纳入阴虚证处方467首,涉及中药302种,药物四气以寒为主,五味以甘为主,归经以肾经为主,核心中药包括熟地黄、麦冬、生地黄、当归等;常用药对包括山药-熟地黄、山萸肉-熟地黄、茯苓-熟地黄,高频药物可聚类为2类。结论揭示了古代治疗阴虚证以滋阴降火为主,重视补养肾阴的同时亦注重补养肺、肝、脾阴,养阴时常配伍健脾和辛散退热类药物的用药规律,可为临床治疗阴虚证提供参考。

Objective The data mining method was used to analyze the medication rules of the ancient prescriptions for yin deficiency syndrome,so as to provide reference for clinical treatment of yin deficiency syndrome.Methods We searched the database of ancient prescriptions,selected the prescriptions for yin deficiency syndrome,used the Ancient and Modern Medical Case Cloud Platform V2.2.3 to count the frequency and attribute of drug use,and carried out hierarchical cluster analysis to find the core prescription.MATLAB was used to analyze the association rules,and the law of drug compatibility was found.The Pajek645.13 was used for complex network analysis to find out the core traditional Chinese medicine.Results There were 467 prescriptions that meet the requirements,302 kinds of drugs were used in total.The four properties of the drugs were mainly cold,the five flavors mainly sweet,the meridian of the drugs mainly kidney meridian.The core drugs were Rehmanniae Radix Praeparata,Ophiopogonis Radix,Rehmanniae Radix,and Poria.The most commonly used drug pair was Dioscoreae Rhizoma-Rehmanniae Radix Praeparata,the second was Corni Fructus-Rehmanniae Radix Praeparata,Poria-Rehmanniae Radix Praeparata.The commonly used drugs can be clustered into two categories.Conclusion We can preliminarily reveal that the ancient medication law of yin deficiency syndrome is mainly nourishing Yin liquid and reducing fire,paying attention to nourishing kidney yin,using Yin nourishing medicine often combined with medicine of tonifying lung,liver,spleen yin and diverging to reduce fever.It can provide certain reference for clinical treatment of yin deficiency syndrome.