摘要
以(取代)苯甲醛及盐酸氨基脲为原料,合成了中间体芳醛缩氨脲。再以1,4-二氧六环为溶剂,在无水碳酸钾与碘的作用下反应得到2-氨基-5-芳基-1,3,4-噁二唑。实验结果表明,2-氨基-5-芳基-1,3,4噁二唑优化合成条件为:n(苯甲醛缩氨脲)∶n(无水碳酸钾)∶n(碘)=1.0∶1.5∶0.6,反应温度80℃,反应时间6 h,产率84%以上。
The aromatic aldehyde semicarbazone intermediates were synthesized using arylaldehyde and semicarbazide hydrochloride as raw materials,and then 2-amino-5-aryl-1,3,4-oxadiazole were synthesized using arylaldehyde semicarbazone in 1,4-dioxane in the presence of iodine and anhydrous K_(2)CO_(3).The reaction conditions were optimized,the best synthetic conditions for 2-amino-5-aryl-1,3,4 oxadiazole are:the n(semicarbazone)∶n(anhydrous K_(2)CO_(3))∶n(iodine)ratio is 1.0∶1.5∶0.6,the reaction temperature is 80℃,the reaction time is 6 h,and the yield is above 84%.
作者
尹大伟
王龙瑞
刘玉婷
李金泽
刘英
Yin Dawei;Wang Longrui;Liu Yuting;Li Jinze;Liu Ying(Institute of Frontier Science and Technology Transfer, Shaanxi University of Science & Technology, Xi’an 710021, Shaanxi, China;College of Chemistry and Chemical Engineering,Key Laboratory of Auxiliary Chemistry & Technology for Chemical Industry, Ministry of Education, Shaanxi University of Science & Technology, Xi’an 710021, Shaanxi, China)
出处
《精细石油化工》
CAS
2022年第1期18-22,共5页
Speciality Petrochemicals
基金
国家自然科学基金项目(No.21706152)
陕西省科技计划项目(No.2021GY-162)。
