冠状病毒感染性疾病法医病理学改变的回顾与思考

Review and Thinking on Forensic Pathological Changes of Coronavirus-Infected Diseases

21世纪以来,已经有3种冠状病毒在人群间广泛传播并造成严重的疾病与死亡,强烈提示冠状病毒感染引发的高传染性疾病并非偶发事件。冠状病毒感染性疾病以呼吸系统症状为主要表现,但同时存在多器官功能障碍。精准探明冠状病毒感染性疾病的病理过程、特征和发生机制,有助于认识其临床特征,为探寻针对性的防治策略提供病理学依据。本文简要回顾已知的冠状病毒感染性疾病的病理学研究发现,尝试构建冠状病毒感染性疾病的病变谱,旨在为开展冠状病毒感染性疾病的尸体解剖、组织病理学检验与动物感染模型研究等提供借鉴与思考。

Since the beginning of this century,three types of coronavirus have widely transmitted and caused severe diseases and deaths,which strongly indicates that severe infectious diseases caused by coronavirus infection are not accidental events.Coronavirus-infected diseases are mainly manifested by respiratory symptoms,with multiple organ dysfunctions.Precisely investigating the pathological process,characteristics and pathogenesis of coronavirus-infected diseases will be beneficial for us to understand clinical manifestations and provide targeted suggestions on prophylaxis and treatment.This paper briefly reviews the pathological findings of three known coronavirus-infected diseases,and attempts to construct the pathological spectrum of coronavirus-infected diseases,aiming to provide reference and thinking for autopsy,histopathological examination and animal infection model study of coronavirusinfected diseases.