MTHFR基因多态性与女性不孕症关系的meta分析

Association of MTHFR gene polyorphisms with the risk of female infertility:A meta-analysis

目的:探讨MTHFR(C677T、A1298C)基因多态性与女性不孕症风险关系。方法:计算机检索PubMed、Web of Science、CNKI、WanFang、VIP和CBM等中英文数据库,检索时限为建库至2021年7月。搜集关于MTHFR C677T和A1298C基因多态性与女性不孕症相关的病例对照研究。采用Stata软件在5个模型中进行meta分析,并计算优势比及95%置信区间评价其关联度,同时进行敏感性分析及发表偏移的评估。结果:共纳入12项研究。meta分析结果显示,MTHFR基因多态性(C677T、A1298C)与女性不孕症风险无相关性。MTHFR C677T基因的5种模型T比C(OR=1.11,95%CI 0.97-1.26)、TT比CC(OR=1.27,95%CI 0.98-1.64)、CT比CC(OR=1.08,95%CI 0.90-1.31)、(TT+CT)比CC(OR=1.12,95%CI 0.93-1.36)和TT比(CC+CT)(OR=1.04,95%CI 0.97-1.10),提示C677T多态性与女性不孕症发生不存在相关性;MTHFR A1298C基因的5种模型C比A(OR=1.00,95%CI 0.92-1.09)、CC比AA(OR=0.99,95%CI 0.60-1.62)、AC比AA(OR=1.00,95%CI 0.89-1.12)、(CC+AC)比AA(OR=1.00,95%CI 0.90-1.11)和CC比(AC+AA)(OR=0.95,95%CI 0.57-1.57),提示A1298C多态性与女性不孕症不存在相关性。结论:MTHFR基因多态性(C677T、A1298C)与女性不孕症风险未见相关性。

Objective:To explore the association of MTHFR(C677T and A1298C)single nucleotide polymorphisms with the risk of female infertility.Methods:Databases including PubMed,Web of Science,CNKI,Wanfang,VIP,and CBM were searched,and the searched time limit was from database establishment up to July 2021.The case-control studies about the association of MTHFR(C677T and A1298C)polymorphisms with the risk of female infertility were collected.State software was used to evaluate the association of MTHFR polymorphisms of the women with their risk of infertility by 95%confidence interval,odds ratio,publication bias,and heterogeneity in five models.Results:A total of 12 case-control studies were included.Meta-analysis showed that MTHFR gene(C677T and A1298C)polymorphisms of the women was not associated with their risk of infertility.5 kinds models of MTHFR C677T were T vs.C(OR=1.11,95%CI 0.97-1.26),TT vs.CC(OR=1.27,95%CI 0.98-1.64),CT vs.CC(OR=1.08,95%CI 0.90-1.31),(TT+CT)vs.CC(OR=1.12,95%CI 0.93-1.36),and TT vs.(CC+CT)(OR=1.04,95%CI 0.97-1.10),respectively,which suggested that MTHFR C677T gene polymorphism was not associated with the occurrence of female infertility.5 kinds models of MTHFR A1298C were C vs.A(OR=1.00,95%CI 0.92-1.09),CC vs.AA(OR=0.99,95%CI 0.60-1.62),AC vs.AA(OR=1.00,95%CI 0.89-1.12),(CC+AC)vs.AA(OR=1.00,95%CI 0.90-1.11),and CC vs.(AC+AA)(OR=0.95,95%CI 0.57-1.57),respectively,which also suggested that MTHFR A1298C gene polymorphism was not associated with the occurrence of female infertility.Conclusion:MTHFR(C677T and A1298C)gene polymorphisms of the women maybe no associated with their risk of infertility.