职业女性卵巢早衰的影响因素调查

Investigation and analysis of the influence factors of premature ovarian failure of professional women

目的:探讨职业女性卵巢早衰(POF)相关危险因素。方法:采用病例对照研究方法,对2018年3月-2020年10月在本医院门诊276例职业女性POF患者(POF组)和524例正常女性(对照组)进行病史采集以及艾森克个性问卷、职业紧张目录问卷调查。采用多因素logistic回归分析POF的主要影响因素。结果:盆腔手术史(OR=2.117,95%CI 1.304~3.435)、腮腺炎病史(OR=1.915,95%CI 1.208~3.036)、人工流产史(OR=1.128,95%CI 1.107~1.150)、精神质(OR=1.344,95%CI 1.325~1.363)、任务模糊(OR=1.376,95%CI 1.343~1.409)和任务界限不清(OR=1.263,95%CI 1.229~1.299)为POF危险因素;而外向型性格为保护因素(OR=0.651,95%CI 0.651~0.695)。结论:盆腔手术史、腮腺炎病史、人工流产次数、精神质、任务模糊和任务界限不清为职业女性POF的危险因素,外向型性格是职业女性POF的保护因素。

Objective:To study the risk factors of premature ovarian failure(POF)of professional women.Methods:A case-control study was conducted on 276 professional women with POF in study group and 524 professional women in control group.Detailed medical histories of the women in the two groups were collected,and Eysenck Personality Questionnaire and Occupational stress inventory Revised Edition(OSI-R)were used in this survey.Multiple Logistic regression was used to analyze the main influencing factors of POF.Results:History of pelvic surgery(OR=2.117,95%CI 1.304-3.435),history of mumps(OR=1.915,95%CI 1.208-3.036),history of induced abortion(OR=1.128,95%CI 1.107-1.150),psychoticism(OR=1.344,95%CI 1.325-1.363),task ambiguity(OR=1.376,95%CI 1.343-1.409),and unclear boundaries of task(OR=1.263,95%CI 1.229-1.299)of the women were the risk factors of their POF.Extraversion personality was the protective factor of their POF(OR=0.651,95%CI 0.651-0.695).Conclusion:Pelvic surgery history,mumps history,abortion frequency,psychoticism,task ambiguity,and unclear boundaries of task of the women are the risk factors of their POF.Extraversion personality of the women is the protective factor of their POF.