125例辅助生殖反复种植失败患者不良心理及生活质量调查

Survey of adverse psychological status and quality of life of 125 women with recurrent implantation failure after assisted reproduction

目的:分析辅助生殖反复种植失败患者不良心理及生活质量影响因素。方法:选取在本院行辅助生育技术治疗反复种植失败的不孕症患者125例作为研究对象,发放症状自评量表(SCL-90)和简易生活质量量表(SF-36),分析影响反复种植失败患者生活质量的相关因素。结果:被调查患者SCL-90评分焦虑、抑郁得分最高(3.89±0.33分、3.70±0.42分),焦虑因子阳性率最高(60.0%)、抑郁次之(49.6%)、再次为躯体化(32.0%)。SF-36总分(66.30±2.26分),各维度中一般健康维度得分最高(68.85±3.47分)、精神健康维度最低(64.24±2.39分)。不同婚姻状况、家庭年收入、不孕年限、不孕原因、不孕治疗年限患者的SF-36评分有差异(P<0.05)。焦虑、抑郁及人际关系敏感阳性者SF-36评分均高于非阳性者(P<0.05)。多因素分析显示,家庭年收入、不孕年限、不孕治疗年限、配偶是否独生子女、种植失败次数、焦虑、抑郁均是反复种植失败患者生活质量的重要影响因素(P<0.05)。结论:辅助生殖反复种植失败患者普遍存在明显的焦虑、抑郁情绪,心理状况及生活质量均不理想,种植失败次数、配偶为独生子女、焦虑、抑郁等是影响其生活质量的主要因素。

Objective:To understand the adverse psychological status and quality of life of 125 women with recurrent implantation failure(RIF)after assisted reproduction,and to analyze the factors influencing their quality of life.Methods:125 infertile patients with RIF after assisted reproduction were selected as the research objects.The symptom checklist 90(SCL-90)and simple quality of life scale(SF-36)were distributed to these women.The factors influencing the quality of life of these women were analyzed.Results:The SCL-90 score and the highest score of anxiety and depression of the women were 3.89±0.33 points and 3.70±0.42 points.The positive rate(60.0%)of anxiety factor of the women was the highest,followed by that(49.6%)of depression factor,and then was that(32.0%)of somatization factor.The total score of SF-36 was 66.30±2.26 points,and among the different dimensionalities of SF-36,the score of general health(68.85±3.47)was the highest,and the score of mental health(64.24±2.39)was the lowest.SF-36 score had significant different among the women with different marital status,the women with different annual family income,the women with different duration of infertility,the women with different causes of infertility,or the women with different years of infertility treatment(P<0.05).SF-36 score of the women with anxiety,depression,or interpersonal sensitivity were significantly higher than those of the women without anxiety,depression,or interpersonal sensitivity(P<0.05).Multivariate analysis showed that annual family income,duration of infertility,years of infertility treatment,whether the spouse was the only child,the times of implantation failures,anxiety,and depression of the women with RIF were the important factors influencing their quality of life(P<0.05).Conclusion:The women with RIF after assisted reproduction generally have obvious anxiety and depression,and their psychological status and quality of life are not ideal.The times of RIF,their spouse is the only child,anxiety,and depression status are the main factors affecting their quality of life.