间苯三酚联合那屈肝素治疗复发性流产对患者妊娠结局及性激素水平影响

Influence of phloroglucinol combined with nadroparin for treating patients with recurrent abortion on their pregnancy outcomes and sex hormone levels

目的:探讨间苯三酚联合那屈肝素治疗复发性流产对患者分娩结局及血清雌二醇(E_(2))、绒毛膜促性腺激素(HCG)、孕酮(P)水平的影响。方法:选取2019年1月-2019年12月因复发性流产来本院接受治疗的90例患者为研究对象,随机分组,对照组采用那屈肝素治疗,观察组采用那屈肝素与间苯三酚联合治疗。比较两组分娩结局、治疗前后性激素水平以及不良反应情况。结果:观察组足月分娩率(84.4%)高于对照组(60.0%),流产率(4.4%)低于对照组(22.2%)(均P<0.05),早产率两组无差异(P>0.05);治疗后观察组HCG、P及E_(2)水平均高于对照组(P<0.05),不良反应观察组与对照组(8.9%、13.3%)无差异(P>0.05)。结论:对复发性流产患者采用间苯三酚联合那屈肝素治疗,患者凝血功能指标与HCG、P及E_(2)水平均得到明显改善,有助于改善分娩结局,未增加不良反应。

Objective:To investigate the influence of phloroglucinol combined with nadroparin for treating patients with recurrent abortion(RA)on their delivery outcomes and their levels of serum estradiol(E_(2)),chorionic gonadotropin(HCG),progesterone(P).Methods:A total of 90 patients with RA were selected as the study subjects and were randomly divided to study group and control group from January 2019 to December 2019.The patients in the control group were treated with nadroparin,while patients in the study group were treated with phloroglucinol combined with nadroparin.The delivery outcomes,the sex hormone levels before and after treatment,and the adverse reactions of the patients were compared between the two groups.Results:The rate of full term delivery(84.4%)of the patients in the study group was significantly higher than that(60.0%)of the patients in the control group,and the abortion rate(4.4%)of the patients in the study group was significantly lower than that(22.2%)of the patients in the control group(P<0.05).There was no significant difference in the premature delivery rate of the patients between the two groups(P>0.05).After treatment,the levels of HCG,P,and E_(2) of the patients in the study group were significantly higher than those of the patients in the control group(P<0.05),and there was no significant difference in the adverse reaction rate(8.9%vs.13.3%)of the patients between the two groups(P>0.05).Conclusion:Phloroglucinol combined with nadroparin for treating patients with RA improves their levels of HCG,P,and E_(2) significantly,which is helpful to improve their delivery outcomes,and has higher safety without increasing the adverse reactions.