子宫内膜异位症患者血清Flk-1、COX-2水平及与病情、疼痛关系

The levels of serum fetal liver kinase and cyclooxygenase-2serum of women with endometriosis and their correlation with the endometriosis condition and pain degree

目的:探讨子宫内膜异位症(EMT)患者血清胎肝激酶(Flk)-1、环氧化酶-2(COX-2)水平变化及与病情、疼痛程度关系。方法:选择2019年1月-2020年12月EMT患者112例为EMT组,根据视觉模拟量表(VAS)评估盆腔疼痛程度分为无痛组(n=23)、轻度疼痛组(n=26)、中度疼痛组(n=45)与重度疼痛组(n=18);根据美国生育协会修正分期法(r-AFS)分为Ⅰ期(n=16)、Ⅱ期(n=44)、Ⅲ期(n=29)、Ⅳ期(n=23);体检健康育龄妇女70例为对照组。检测各组血清Flk-1、COX-2水平,并与疼痛程度进行相关性分析。结果:EMT组血清Flk-1(26.60±7.44ng/ml)、COX-2(3.16±0.53ng/ml)高于对照组(6.52±1.13ng/ml、1.42±0.31ng/ml)(P<0.05)。EMT组血清Flk-1、COX-2水平随疼痛VAS评分和R-AFS分期的升高而增加(P<0.05)。线性相关性分析显示,血清Flk-1与COX-2水平正相关,且均与VAS评分、R-AFS分期正相关性(r=0.781、0.658,0.792、0.708,P<0.05)。结论:EMT患者血清Flk-1、COX-2异常高表达,且与疾病分期及疼痛程度有关,可为临床病情的评估及治疗提供参考。

Objective:To investigate the changes of serum fetal liver kinase(Flk)-1 and cyclooxygenase-2(COX-2)levels of women with endometriosis(EMs),and to study their correlation with the degree of pain and the EMs condition of the women.Methods:A total of 112 women with EMs were selected in study group between January 2019 to December 2020,and which were further divided into group A(23 women with painless),group B(26 women with mild pain),group C(45 women with moderate pain),and group D(18 women with severe pain)according to the degree of pelvic pain by Visual Analog Scale(VAS),and which were also further divided into group E(16 women with stage I of EMs),group F(44 women with stage II of EMs),group G(29 women with stage III of EMs),and group H(23 women with stage IV of EMs)according to the EMs condition by the American Fertility Association's revised staging method(r-AFS).70 healthy women of childbearing age were selected in control group.The serum levels of Flk-1 and COX-2 of the women in these group were detected,and their correlation with the degree of pain of the women were analyzed.Results:The levels of serum FLK-1(26.60±7.44ng/ml)and COX-2(3.16±0.53ng/ml)of the women in the study group were significantly higher than those(6.52±1.13ng/ml and 1.42±0.31ng/ml)of the women in the control group(P<0.05).The levels of Flk-1 and COX-2 of the women in the study group had increased with their increasing VAS score and R-AFS stage(P<0.05).Linear correlation analysis showed that serum FLK-1 level of the women was positively correlated with their serum COX-2 level,and the levels of Flk-1 and COX-2 of the women were positively correlated with their VAS score and R-AFS stage(R=0.781,0.658,0.792,and 0.708,P<0.05).Conclusion:The women with EMs have obvious high expressions of the serum Flk-1 and COX-2,which are closely related to their EMs stage and their degree of pain,which can provide reference for clinical evaluation and treatment of EMs.