卡前列素氨丁三醇联合宫纱填塞治疗宫缩乏力性产后出血效果

Effect of carprost ambutritol combined with uterine gauze packing for treating women with postpartum hemorrhage because of uterine weakness

目的:探讨卡前列素氨丁三醇溶液联合宫纱填塞治疗宫缩乏力性产后出血效果。方法:收集本院2015年5月-2017年5月确诊并治疗的产后出血患者86例临床资料,依据不同治疗方式分组,对照组应用卡前列素氨丁三醇溶液,联合组在对照组基础上联合应用宫纱填塞。比较两组干预后出血量、成功止血时间及月经恢复情况;两组治疗前后抗苗勒氏管激素(AMH)、雌二醇(E_(2))及卵泡刺激素(FSH)水平;两组再次妊娠结局。结果:联合组治疗后2h(351.4±98.5 ml)、12h(105.6±12.3 ml)出血量均低于对照组(468.2±152.4 ml、246.8±10.5 ml),成功止血时间(7.1±0.5h)低于对照组(12.3±2.6h)(均P<0.05),两组产后月经恢复,AMH、E_(2)及FSH水平,再次妊娠、足月活产、早产及自然流产情况均无差异(P均>0.05)。结论:对宫缩乏力性产后出血患者应用卡前列素氨丁三醇溶液联合宫纱填塞治疗,可显著缩短成功止血时间,降低出血量,且不会对患者产后月经恢复、卵巢功能及再妊娠产生影响。

Objective:To investigate the effect of carprost ambutritol combined with uterine gauze packing for treating women with postpartum hemorrhage because of uterine weakness.Methods:The clinical data of 86 women with postpartum hemorrhage from May 2015 to May 2017 were collected.The women were divided into two groups according to different treatment methods.The women in the control group were treated with carprost ambutritol solution,and the women in the study group were treated with carprost ambutritol solution combined with uterine gauze packing.The amount of blood loss,the time of successful hemostasis,and the menstrual recovery situation of the women after intervention were compared between the two groups.The levels of anti-mullerian tubule hormone(AMH),estradiol(E_(2)),and follicle stimulating hormone(FSH)of the women before and after treatment were compared between the two groups.And the pregnancy outcomes of the women after intervention were also compared between the two groups.Results:The blood loss(351.4±98.5 ml)in 2h after treatment or(105.6±12.3 ml)in 12h after treatment of the women in the study group was significantly lower than that(468.2±152.4 ml or 246.8±10.5 ml)of the women in the control group.The time of successful hemostasis(7.1±0.5h)of the women in the study group was significantly lower than that(12.3±2.6h)of the women in the control group(all P<0.05).Postpartum menstrual recovery,the levels of AMH,E_(2),and FSH,the situation of pregnancy again,and the situations of full term live birth,premature delivery,and spontaneous abortion of the pregnancy again of the women had no significant different between the two groups(all P>0.05).Conclusion:The application of carprost ambutritol solution combined with uterine gauze packing for treating women with postpartum hemorrhage because of uterine weakness can significantly shorten the time of successful hemostasis and can reduce their amount of blood loss,and which will not influence the postpartum menstrual recovery,ovarian function,and pregnancy again of the women.