舒芬太尼和瑞芬太尼分别复合异丙酚用于无痛人工流产术效果

Effect of sufentanil or remifentanil combined with propofol during painless induced abortion

目的:比较舒芬太尼和瑞芬太尼分别复合异丙酚在无痛人工流产术中效果。方法:选择2017年8月-2018年12月于本院产科行无痛人工流产术者126例。随机数字表法分为舒芬太尼复合异丙酚组或瑞芬太尼复合异丙酚组各63例。比较两组麻醉效果、麻醉前后生命体征及不良反应发生。结果:麻醉效果合格率舒芬太尼复合异丙酚组61例(96.8%),瑞芬太尼复合异丙酚组62例(98.4%),两组无差异(P>0.05)。麻醉后,两组心率和血氧饱和度未见差异,但动脉平均压舒芬太尼复合异丙酚组高于瑞芬太尼复合异丙酚组(P<0.05)。术后舒芬太尼复合异丙酚组发生头晕4例,恶心呕吐2例,心动过缓2例,总不良事件发生率为12.7%;瑞芬太尼复合异丙酚组发生头晕3例,恶心呕吐5例,心动过缓1例,总不良事件发生率为14.3%,两组无差异(P<0.05)。结论:在无痛人工流产手术中采用复合静脉麻醉方案(舒芬太尼联合丙泊酚或瑞芬太尼联合异丙酚)均可获得满意的麻醉效果,两组麻醉效果和不良反应发生率无明显差异。

Objective:To compare the different effect of sufentanil or remifentanil combined with propofol during painless induced abortion.Methods:126 women who underwent painless abortion were selected and were divided into group A(63 women with sufentanil combined with propofol)and group B(63 women with remifentanil combined with propofol)by random number table method from August 2017 to December 2018.The effect of anesthesia,the vital signs before and after anesthesia,and the rate of adverse reactions of the women were compared between the two groups.Results:There were no significant differences in the rate of qualified anesthetic effect(96.8%,61 cases vs.98.4%,62 cases)of the women between the two groups(P>0.05).After anesthesia,there were no significant differences in the values of the heart rate and the oxygen saturation of the women between the two groups,but the mean arterial pressure value of the women in group A was significantly higher than that of the women in group B(P<0.05).In group A,there were 4 women with dizziness,2 women with nausea and vomiting,and 2 women with bradycardia,and the total incidence of adverse events of the women was 12.7%.In group B,there were 3 women with dizziness,5 women with nausea and vomiting and 1 case woman with bradycardia,and the total incidence of adverse events of the women was 14.3%.There was no significant difference in the total incidence of adverse events of the women between the two groups(P<0.05).Conclusion:The anesthetic effect of sufentanil or remifentanil combined with propofol during painless induced abortion is satisfaction.The anesthetic effect and the total incidence of adverse events of the women with sufentanil combined with propofol for anesthesia has no significant different from those of remifentanil combined with propofol.