子宫内膜异位症患者血清IL-17、IL-23、BDNF表达及其相关性

IL-17,IL-23 and BDNF expression in serum of edometriosis patients and their correlation

目的:观察子宫内膜异位症(EMT)患者血清白介素-17(IL-17)、IL-23、脑源性神经营养因子(BDNF)表达及其相关性。方法:选择2019年6月—2021年1月本院收治的EMT患者104例(EMT组),根据美国生育学会修订(R-AFS)分期标准分为Ⅰ期13例、Ⅱ期27例、Ⅲ期39例、Ⅳ期25例;健康体检育龄女性80例为对照组。检测并比较各组血清IL-17、IL-23、BDNF水平,线性回归分析R-AFS分期与IL-17、IL-23、BDNF相关性。结果:EMT组血清IL-17、IL-23、BDNF水平均高于对照组,且随着R-AFS分期进展血清水平升高(P<0.05)。R-AFS分期与IL-17、IL-23、BDNF呈正相关性(r=0.906、0.917、0.695,P<0.05),IL-17、IL-23、BDNF之间呈正相关性(P<0.05)。二分类logistic回归分析显示,IL-17、IL-23、BDNF及其交互作用均为EMT患者R-AFS高分期的独立危险因素(P<0.05)。结论:血清IL-17、IL-23、BDNF在EMT患者中呈高表达,且随R-AFS分期的升高而增加,3者可能相互作用影响着EMT的病情进展。

Objective:To observe the expression and the correlation of serum interleukin-17(IL-17),interleukin-23(IL-23),and brain-derived neurotrophic factor(BDNF)of the patients with endometriosis(EMT).Methods:A total of 104 patients with EMT were selected in group A between June 2019 and January 2021.According to R-AFS staging,the patients in group A were divided into 13 cases with stage I in group A1,27 cases with stage II in group A2,39 cases with stage III in group A3,and 25 cases with stage IV in group A4.In addition,80 healthy women of childbearing age were selected in the control group during the same period.The serum levels of IL-17,IL-23,and BDNF of the patients in the five groups were detected and compared.The correlation between R-AFS staging and IL-17,IL-23,and BDNF levels was analyzed by linear regression.Results:The levels of serum IL-17,IL-23,and BDNF of the patients in group A were significant higher than those of the patients in the control group,and with the increasing of R-AFS stage,the levels of serum IL-17,IL-23,and BDNF of the patients in group A had increased significantly(P<0.05).The R-AFSR staging of the patients in group A was positively correlated with their levels of IL-17,IL-23,and BDNF(r=0.906,0.917,0.695,P<0.05).There were positive correlations among the IL-17 level,IL-23 level,and BDNF level(P<0.05).Binary logistic regression analysis showed that the levels of IL-17,IL-23,and BDNF,and their interactions were all the independent risk factors of high stage R-AFS of the patients with EMT(P<0.05).The expressions of the IL-17,IL-23,and BDNF levels of the patients with EMT are high,and which increase with the increasing of R-AFS staging.The serum IL-17,IL-23,and BDNF levels may affect the progression of EMT by synergistic effect each other.