伊立替康联合顺铂同步放化疗治疗中晚期宫颈癌疗效及对患者疼痛和生活质量影响

Efficacy of concurrent chemoradiotherapy by irinotecan combined with cisplatin for treating patients with advanced cervical cancer,and its influence on the their pain and quality of life

目的:分析伊立替康联合顺铂同步放化疗治疗中晚期宫颈癌临床疗效及对患者疼痛程度及生活质量的影响。方法:回顾性分析2017年1月—2020年1月于本院就诊的中晚期宫颈癌患者80例临床资料,按治疗方式分组,对照组40例予顺铂同步放化疗治疗,观察组40例予伊立替康联合顺铂同步放化疗治疗,比较两组临床疗效、疼痛程度、生活质量、不良反应及肿瘤细胞增殖凋亡情况。结果:治疗后,观察组总有效率(87.5%)高于对照组(62.5%)(P<0.05);两组PANA、A-L1水平均明显改善且观察组改善情况优于对照组,两组QCL评分增加、VAS评分下降且观察组评分改善优于对照组(P<0.05);两组均出现贫血、白细胞减少及中性粒细胞减少等症状,但组间无差异(P>0.05);观察组出现恶心26例(65.0%)、呕吐26例(65.0%)、腹泻21例(52.5%)较对照组恶心10例(25.0%)、呕吐10例(25.0%)、腹泻12例(30.0%)高(P<0.05)。结论:伊立替康联合顺铂同步放化疗治疗中晚期宫颈癌临床疗效佳,可减轻患者疼痛程度,降低不良反应改善生活质量。

Objective:To analyze the clinical efficacy of concurrent chemoradiotherapy by irinotecan combined with cisplatin for treating the patients with advanced cervical cancer,and to study its influence on the pain degree and quality of life of the patients.Methods:The clinical data of 80 patients with advanced cervical cancer from January 2017 to January 2020 were analyzed retrospectively.According to different treatments,these patients were divided into observation group and control group(40 cases in each group).The patients in the control group were treated by concurrent chemoradiotherapy of cisplatin,and the patients in the observation group were treated by concurrent radiochemotherapy of irinotecan combined with cisplatin.The clinical efficacy,pain degree,quality of life,incidence of adverse reactions,and proliferation and apoptosis of tumor cell of the patients were compared between the two groups.Results:The total effective rate of the patients in the observation group(87.5%)was significant higher than that(62.5%)of the patients in the control group(P<0.05).After treatment,the PANA and A-L1 levels of the patients in both groups had increased significantly,and the improvement of which of the patients in the observation group were significant better than those of the patients in the control group.QCL score of the patients in in both groups had increased significantly,VAS score of the patients in in both groups had decreased significantly,and the improvement of which of the patients in the observation group were significant better than those of the patients in the control group(P<0.05).Anemia,leukopenia,and neutropenia were observed in the patients in both groups,but there were no significant differences in the incidences of anemia,leukopenia,and neutropenia of the patients between the two groups(P>0.05).The rates of nausea(26 cases,65.0%),vomiting(26 cases,65.0%),and diarrhea(21 cases,52.5%)of the patients in the observation group were significant higher than those(10 cases,25.0%;10 cases,25.0%;and 12 cases,30.0%)of the patients in the control group(P<0.05).Conclusion:Concurrent chemoradiotherapy of irinotecan combined with cisplatin for treating the patients with advanced cervical cancer has good efficacy,which can reduce their pain degree,and can improve their quality of life.