富马酸亚铁多库酯钠胶囊联合多糖铁复合物、健脾生血颗粒治疗妊娠期缺铁性贫血疗效

Clinical curative effect analysis of ferrous eumanate and docusate sadium capsule combined with Jianpi shengxue granule or polysaccharide-iron complex for treating pregnant women with iron deficiency anemia

目的:探讨富马酸亚铁多库酯钠胶囊联合健脾生血颗粒、多糖铁复合物治疗妊娠期缺铁性贫血(IDA)的临床疗效。方法:采用前瞻性研究方法,选取150例IDA孕妇为研究对象,随机数字表法分为A、B、C组,每组50例,A组给予多糖铁复合物治疗,B组给予多糖铁复合物和健脾生血颗粒治疗,C组给予多糖铁复合物、健脾生血颗粒和富马酸亚铁多库酯钠胶囊,连续治疗4周,对比3组临床疗效。结果:B组与C组的总有效率(88.0%,96.0%)均高于A组(82.0%),差异有统计学意义(P<0.05)。治疗后红细胞数(RBC)﹑血红蛋白(Hb)﹑平均红细胞体积(MCV)﹑血清铁(SI)﹑血清铁蛋白(SF)﹑转铁蛋白饱和度(TSAT)水平,B组与C组无差异,但均高于A组(P<0.05);C组便秘发生率(6%)低于A组(24%)和B组(26%)(P<0.05);3组不良围产期结局比较无差异(P>0.05)。结论:妊娠期IDA孕妇在使用常规铁剂改善贫血同时给予健脾生血颗粒可提高贫血治疗效果且安全,有效改善孕妇便秘情况。

Objective:To explore the clinical curative effect of ferrous eumanate and docusate sadium capsule combined with Jianpi shengxue granule for treating pregnant women with iron deficiency anemia(IDA).Methods:A total of 120 pregnant women with IDA were prospectively selected and randomly divided into three groups(50 cases in each group)by random number table.The women in group A were given polysaccharide-iron complex,the women in group B were given polysaccharide-iron complex and ferrous eumanate and docusate sadium capsule,and the women in group C were given polysaccharide-iron complex,ferrous eumanate and docusate sadium capsule,and Jianpi shengxue granule.The women in the three groups were treated for 4 weeks.The clinical efficacy of the women was compared among the three groups.Results:The total effective rate of the women in group B(88.0%)or group C(96.0%)was significantly higher than that(82.0%)of the women in group A(P<0.05).After treatment,there were no significant differences in the values of red blood cell,hemoglobin,and mean corpuscular volume,and the levels of serum iron,serum ferritin,and transferrin saturability of the women between group B and group C(P>0.05),but which of the women between group B and group C were all significantly higher than those of the women in group A(P<0.05).The incidence of constipation of the women in group C was 6%,which was significantly lower than that(24%)of the women in group A or that(26%)of the women in group B(P<0.05).There was no significant difference in perinatal outcomes of the women among the three groups(P>0.05).Conclusion:The anemia situation of the pregnant with IDA can be improved by routine iron supplementation treatment,and Jianpi shengxue granules used for the treatment additionally can further improve the therapeutic effect of anemia with good safety.The constipation status of the pregnant women can be improved by sodium ferrous fumarate capsule.