子痫前期患者血清白蛋白、整合素β1水平及诊断疾病意义

The levels of serum albumin and ITGβ-1 of pregnant women with preeclampsia and its diagnostic significance

目的:探究子痫前期(PE)患者血清白蛋白(HSA)、整合素β1(ITGβ-1)水平及诊断意义。方法:回顾性分析2018年1月-2020年12月本院收治的PE患者97例(PE组),按照病情严重程度分为重度(n=34)和轻度(n=63),产前检查正常孕妇35例为对照组,检测各组血清HSA、ITGβ-1水平并分析与PE病情严重程度关系及对PE的诊断价值。结果:PE组分娩前血压、血肌酐、24h尿蛋白、血清ITGβ-1水平均高于对照组,分娩孕周、血清HSA水平低于对照组,且重度患者变化幅度大于轻度患者(均P<0.05);Pearson相关性分析显示,PE患者血清ITGβ-1与血压呈正相关(r=0.695、0.710,P<0.05),血清HSA与血压呈负相关(r=-0.772、-0.704,P<0.05);建立血清HSA、ITGβ-1诊断PE的ROC曲线,其AUC分别为0.736、0.731,二者联合诊断的AUC为0.814,高于单一诊断方法(P<0.05)。结论:PE患者存在血清HSA升高和ITGβ-1水平下降,两者均参与了PE发生发展过程,对PE诊断有一定临床价值。

Objective:To explore the levels of serum albumin(HSA)and integrinβ1(ITGβ-1)of pregnant women with preeclampsia(PE),and to study its diagnostic significance for PE.Methods:98 pregnant women with PE from January 2018 to December 2020 were analyzed retrospectively,and these women were divided into group A(34 women with severe PE)and group B(63 women with mild PE)according to the severity of PE.And another 35 normal pregnant women were selected in group C.The levels of serum HSA and ITGβ-1 of the women in the three groups were detected,and the levels of serum HSA and ITGβ-1,and their relevant to the severity of PE,and the value of the levels of serum HSA and ITG for diagnosing PE were analyzed.Results:The blood pressure value and the serum creatinine level,24h urinary protein value,and serum ITGβ-1 level of the women in group A and B before delivery were significantly higher than those of the women in group C,while the gestational weeks and serum HSA level of the women in group A and B were significantly lower than those of the women in group C,and the change ranges of which of the women in group A were significant more than those of the women in group B(all P<0.05).Pearson correlation analysis showed that serum ITGβ-1 level of the women in group A and B was positively correlated with their blood pressure(r=0.695,0.710,P<0.05),but the serum HSA level of the women in group A and B was negatively correlated with their blood pressure(r=-0.772,-0.704,P<0.05).ROC curve of the serum HSA and ITGβ-1 for diagnosing PE was established,and the AUC of the serum HSA and ITGβ-1 for diagnosing PE was 0.736 and 0.731,respectively.The AUC of the combination of serum HSA and ITGβ-1 for diagnosing PE was 0.814,which was significantly higher than that of the serum HAS level or ITGβ-1 level alone(P<0.05).Conclusion:The serum HSA level of the pregnant women with PE increases,but the ITGβ-1 level of them decreases,both of which are involved in the occurrence and development of PE,so they have certain clinical reference value for diagnosing PE.