基于玄府理论针罐结合治疗慢性荨麻疹的临床研究

Clinical efficacy of combination therapy of Needle-pot on chronic urticaria:Based on Xuanfu theory

目的基于玄府理论针罐结合治疗慢性荨麻疹(CU)的临床疗效。方法将84例CU患者按照随机数字表法分为2组,对照组42例予盐酸左西替利嗪口服溶液治疗,治疗组42例予针罐结合治疗,2组均连续治疗4周。比较2组疗效;观察2组治疗前后7 d荨麻疹活动评分(UAS7)、皮肤病生活质量指数(DLQI)评分变化;观察2组治疗前后血清免疫球蛋白E(IgE)、白细胞介素4(IL-4)、干扰素γ(IFN-γ)含量变化;比较2组3次随访复发率。结果治疗组总有效率85.0%(34/40),对照组总有效率82.9%(34/41),2组疗效相当(P>0.05)。2组治疗后UAS7、DLQI评分均较本组治疗前降低(P<0.05);2组治疗后UAS7、DLQI评分比较差异均无统计学意义(P>0.05)。2组治疗后血清IgE、IL-4含量均较本组治疗前降低(P<0.05),IFN-γ较本组治疗前升高(P<0.05);2组治疗后IgE、IL-4、IFN-γ含量比较差异均无统计学意义(P>0.05)。治疗组第1、2、3次随访复发率分别为10.00%(2/20)、15.00%(3/20)、25.00%(5/20),对照组第1、2、3次随访复发率分别为21.05%(4/19)、52.63%(10/19)、73.68%(14/19),治疗组第2、3次随访复发率低于对照组(P<0.05)。结论基于玄府理论针罐结合治疗CU,可改善患者临床症状,提高生活质量,降低血清IL-4、IgE水平,升高血清IFN-γ水平,近期疗效与盐酸左西替利嗪口服溶液相当,但远期疗效优于盐酸左西替利嗪口服溶液。

Objective To explore the clinical effect of combination therapy of Needle-pot on chronic urticaria(CU)based on Xuanfu theory.Methods Totally 84 CU patients were randomly divided into equal group,control group received levocetirizine hydrochloride oral solution,and treatment group received combination therapy of Needle-pot.The treatment continued 4 weeks,aiming to compare curative effect,the weekly Urticaria Activity Score(UAS7),dermatology life quality index(DLQI),serum immunoglobuline(IgE),interleukin-4(IL-4),interferon-gamma(IFN-γ),3-time follow-up recurrence rate.Results The total effective rates in treatment group and control group were 85.0%(34/40)and 82.9%(34/41),respectively,with similar efficacy in groups(P>0.05).After treatment,UAS7 and DLQI scores were decreased in groups in comparison with before treatment,with no statistically significant difference(P>0.05);serum IgE and IL-4 in groups were decreased(P<0.05),serum IFN-γwas increased(P<0.05),the difference was not statistically significant in IgE,IL-4,IFN-γbetween groups(P>0.05).The recurrence rates at the 1st,2nd and 3rd follow-up visits in treatment group and control group were 10.00%(2/20),15.00%(3/20),25.00%(5/20)and 21.05%(4/19),52.63%(10/19),73.68%(14/19),respectively;recurrence rates at the 2nd,3rd follow-up visits were lower in treatment group than in control group(P<0.05).Conclusion For CU patients,combination therapy of Needle-pot based on Xuanfu theory is capable of improving clinical symptoms and quality-of-life,regulating serum IgE and IL-4,and increasing IFN-γlevels.Its long-term effect is better than levocetirizine hydrochloride oral solution,and the short-term effect of the above two was similarity.