低氧环境下帕金森病与骨质疏松的相关性研究进展

Progress of research on the relationship between Parkinson's disease and osteoporosis in hypoxic environments

帕金森病是多见于老年人的神经退行性疾病,严重影响患者的生活质量。骨质疏松亦是老年人的一种常见疾病,以易发生骨折为特征的一种全身代谢性骨骼疾病。有研究证明,帕金森病患者更易患骨质疏松,两者具有高度相关性。而低氧环境可能加重帕金森病患者的病情及并发症,其可能机制为缺氧阻断成骨细胞的生长与分化、促进破骨细胞的形成,增加骨质疏松的风险。研究显示,高海拔地区缺氧、低气压、日光照射强和饮食等因素可能与帕金森病、骨质疏松均有一定的联系。本文就低氧环境下帕金森病与骨质疏松的相关性研究进展进行阐述。

Parkinson's disease is a progressive neurodegenerative disorder often seen in the elderly and seriously affects patients'quality of life.Osteoporosis is also a common systemic metabolic bone disease in the elderly characterized by a predisposition to fractures.Studies have shown that Parkinson's disease is highly correlated with osteoporosis,and patients with Parkinson's disease are at high risk for osteoporosis.Hypoxic environments may aggravate the disease and its complications in patients with Parkinson's disease,and the possible mechanisms may involve inhibition of growth and differentiation of osteoblasts,promotion of the formation of osteoclasts,and thus increased risk of osteoporosis under hypoxic conditions.Recent studies have reported that hypoxia,low air pressure,strong sunlight exposure and diets are associated with Parkinson's disease and osteoporosis at high altitudes.This paper reviews research progress on the relationship between Parkinson's disease and osteoporosis in hypoxic environments.