孤独症谱系障碍儿童的血清胰岛素样生长因子-1和胰岛素样生长因子结合蛋白-3水平研究

Serum levels of insulin-like growth factor-1 and insulin-like growth factor bindingprotein-3 in children with autism spectrum disorder

目的探讨孤独症谱系障碍(autism spectrum disorder,ASD)儿童的血清胰岛素样生长因子-1(insulin-like growth factor-1,IGF-1)和胰岛素样生长因子结合蛋白-3(insulin-like growth factor binding protein-3,IGFBP-3)水平及与孤独症核心症状之间的关系。方法前瞻性选取重庆市妇幼保健院门诊招募的150名2~7岁ASD儿童和165名年龄、性别相匹配的正常健康儿童为研究对象,采用孤独症行为量表和孤独症评定量表评估ASD儿童核心症状,采用化学发光法检测两组儿童血清IGF-1和IGFBP-3水平。结果ASD组儿童血清IGF-1水平低于对照组儿童(P<0.05)。重度ASD儿童血清IGF-1和IGFBP-3水平低于轻-中度ASD儿童(P<0.001),2~3岁ASD儿童血清IGF-1水平低于对照组儿童(P<0.05)。两组男童IGF-1水平均低于女童(P<0.05)。血清IGF-1、IGFBP-3水平与儿童孤独症评定量表总分呈负相关(分别r=-0.32、-0.40,均P<0.001)。结论儿童早期血清IGF-1降低可能与ASD疾病发展相关,血清IGF-1和IGFBP-3水平与ASD儿童核心症状具有一定关联。

Objectives To study the serum levels of insulin-like growth factor-1(IGF-1)and insulin-like growth factor binding protein-3(IGFBP-3)in children with autism spectrum disorder(ASD)and their association with the core symptoms of ASD.Methods A total of 150 ASD children aged 2-7 years(ASD group)and 165 healthy children matched for age and sex(control group)who were recruited at the outpatient service of Chongqing Health Center for Women and Children were enrolled as subjects.Autism Behavior Checklist(ABC)and Childhood Autism Rating Scale(CARS)were used to evaluate the core symptoms of the ASD children.Chemiluminescence was used to measure the serum levels of IGF-1 and IGFBP-3 in both groups.Results The ASD group had a significantly lower serum level of IGF-1 than the control group(P<0.05).The children with severe ASD had significantly lower serum levels of IGF-1 and IGFBP-3 than those with mild-to-moderate ASD(P<0.001).For the children aged 2-3 years,the ASD group had a significantly lower serum level of IGF-1 than the control group(P<0.05).Boys had a significantly lower serum level of IGF-1 than girls in both ASD and control groups(P<0.05).The serum levels of IGF-1 and IGFBP-3 were negatively correlated with the total score of CARS(r=-0.32 and-0.40 respectively,P<0.001).Conclusions The reduction in serum IGF-1 level in early childhood may be associated with the development of ASD,and the serum levels of IGF-1 and IGFBP-3 are associated with the core symptoms of ASD children.