优化靶区设计提高放射免疫疗效

Optimizing the target volume to boost the efficacy of radiation-induced immunomodulatory effects

放疗作为一种重要的肿瘤治疗手段,具备免疫调节作用。放疗联合免疫治疗在特定肿瘤中已经显示出良好的疗效。目前的研究多关注放疗的剂量分割或放疗与免疫治疗的时序问题。随着研究的深入,放疗靶区对机体外周血淋巴细胞以及肿瘤组织微环境的影响,及其与免疫治疗之间的相互作用逐渐被重视。对于局部晚期食管癌等靶区范围较大的肿瘤患者,其放疗一般采用常规分割模式,其联合免疫治疗时靶区大小、计划设计等的设置便显得尤为关键。本文就常规分割放疗联合免疫治疗可行性和靶区优化策略的理论与设想进行阐述。

Radiotherapy is a pivotal method in cancer treatment harbouring immunomodulatory effects.Radiotherapy combined with immunotherapy has been proven to yield promising preliminary results in certain types of tumors.Most studies have concentrated on the dose fractionation of radiotherapy and timing of radiotherapy and immunotherapy.With the development of related studies,attention has been gradually paid to the influence of target volume upon circulating lymphocytes and tumor microenvironment.The interaction between target volume and immunotherapy has been valued.For tumors not suitable for hypofractionated radiotherapy,such as advanced esophageal cancer,conventional fractionated radiotherapy has been adopted.The volume and planning of target volume play a pivotal role in radiotherapy combined with immunotherapy.This article illustrates the feasibility of radiotherapy combined with immunotherapy,theory and conception of optimizing target volume.