期刊文献+

希恩综合征合并糖尿病出现皮肤坏死感染1例治疗体会

下载PDF
导出
摘要 以激素替代为主是治疗希恩综合征首要手段,糖皮质激素是维持希恩综合征患者长期治疗不可或缺激素之一[1]。糖皮质激素具有抗胰岛素样的作用,能抑制组织对葡萄糖的利用促进糖异生和糖原合成,引起高血糖[2]。糖尿病病程较长,血糖控制不良时,加之糖皮质激素治疗易并发高血糖,两者叠加容易导致血糖持续升高。高血糖会造成全身的单核细胞系统功能障碍,导致机体抵抗力下降,易引起菌群失调而诱发各种感染,致使伤口愈合能力受损,如果伤口愈合不良或迁延不愈,可能会致残,严重影响患者生活质量[3]。
出处 《中国乡村医药》 2022年第1期54-55,共2页
  • 相关文献

参考文献4

二级参考文献64

  • 1Singer AJ, Clark RA. Cutaneous wound healing[ J]. N Engl J Med, 1999,341 (10) :738-746.
  • 2Korting HC,Schtillmann C,White RJ. Management of minor a- cute cutaneous wounds: importance of wound healing in a moist environment [ J ]. J Eur Acad Dermatol Venereol, 2011,25 ( 2 ) : 130-137.
  • 3Livant DL,Brabec RK, Kurachi K,et al. The PHSRN sequence induces extracellular matrix invasion and accelerates wound heal- ing in obese diabetic mice [ J ]. J Clin Invest, 2000,105 ( 11 ) : 1537-1545.
  • 4Gurd FB. Postoperative use of insulin in the nondiabetic: with special reference to wound healing [ J ]. Ann Surg, 1937,106 (4) :761-769.
  • 5Rezvani O, Shabbak E, Aslani A, et al. A randomized, double- blind, placebo controlled trial to determine the effects of topical insulin on wound healing[ J]. Ostmny Wound Manage,2009,55 (8) :22-28.
  • 6Taniguchi CM, Emanuelli B, Kahn CR. Critical nodes in signal- ling pathways: insights into insulin action[ J]. Nat Rev Mol Cell Biol,2006,7 ( 2 ) : 85-96.
  • 7Krttger M, Kratchmarova I, Blagoev B,et al. Dissection of the in- sulin signaling pathway via quantitative phosphoproteomics [ J ]. Proc Natl Acad Sci U S A,2008,105(7) :2451-2456.
  • 8Proud CG. Regulation of protein synthesis by insulin [J]. Biochem Soc Trans ,2006,34 ( Pt 2 ) :213-216.
  • 9Walrand S, Guillet C, Gachon P, et al. Insulin regulates protein synthesis rate in leukocytes from young and elderly healthy hu- mans[J]. Clin Nutr,2005,24(6) :1089-1098.
  • 10Walrand S,Guillet C, Boirie Y, et al. In vivo evidences that in- sulin regulates human polymorphonuclear neutrophil functions [J]. JLeukoc Biol,2004,76(6):1104-1110.

共引文献26

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部