有机晶体管生物传感器的探针接枝及其功能化

Development of receptor-modified organic transistor-based biosensing

随着材料开发和溶液加工技术的不断发展,有机电子器件在生物传感领域得到了广泛关注.其中,有机晶体管不仅具备信号转化和信号放大的功能,还可以在溶液环境中低电压、稳定工作,成为发展生物传感器的理想载体之一.为构建高灵敏和高选择性的生物传感器,往往需要对器件进行探针接枝和功能化处理,提高待测物的信号转换效率和降低其他生物物质对待测物的信号干扰.本文从生物识别探针的种类、接枝方式和组装策略出发,概述了有机晶体管生物传感器的特异性传感机制和功能化应用进展,并对新一代有机晶体管传感器的发展做了总结和展望.

With the development of materials and solution-process techniques, organic electronics get increasing attention in bioelectronics. Organic transistors have been considered to be promising candidates for biosensors owing to the functions of signal conversion and amplification, as well as the low operation voltage and long-term stability. In order to realize high sensitivity and selectivity, it is necessary to carry out receptor grafting and surface functionalization,which can facilitate the specific interaction and reduce signal noise. Herein, we summarize recent developments of receptor-functionalized organic transistor-based sensors for smart applications. We first review the fundamentals from the viewpoint of receptor categories, grafting methods and sensing mechanism. Second, we describe the strategies used for receptor assembly and device fabrication. Furthermore, remaining challenges and perspectives are discussed to offer a comprehensive overview of the next generation of corresponding biosensors.