共轭聚合物在生物传感与生物医药领域的研究进展

Recent progress of conjugated polymers in biosensing and biomedical applications

共轭聚合物(CPs)是一类具有离域π-π共轭骨架的高分子材料,在生物医药领域显示了广阔的应用前景.相比于传统的荧光小分子材料,共轭聚合物由于具有优异的光捕获能力、高的单线态氧产率及良好的生物相容性等优势受到了广泛关注.本文从共轭聚合物的结构设计和性能调控的角度出发,重点总结了本课题组近十年来在共轭聚合物的设计合成及其在生物传感、病原菌杀伤、肿瘤治疗上的应用研究,并探讨了当前研究的主要方向和所面临的机遇与挑战.

Conjugated polymers(CPs) with delocalized π–π conjugated backbones have shown broad applications in biomedical fields. Compared with traditional fluorescent small molecules, conjugated polymers have attracted extensive attention due to large optical absorption coefficients, high singlet-oxygen yields and good biocompatibility. Based on the structure design and performance control of conjugated polymers, this article mainly introduces our research progress in the design and synthesis of conjugated polymers and their applications in biosensing, pathogen killing and tumor treatment in the past ten years. It also discusses the main opportunities and challenges in the future.