卟啉–石墨炔衍生物的光热/光动力联合治疗

Photothermal/photodynamic synergetic therapy of functional graphdiyne with porphyrin

在本研究中,我们设计合成了两种卟啉修饰的新型石墨炔衍生物GDYO–TPP和GDY–TPP,它们在有机溶剂和水中具有良好的分散性及优异的生物相容性.研究发现GDYO–TPP和GDY–TPP不仅具有优异的光热转换性能,还具有优异的产生单线态氧能力,并可用于肿瘤的光热/光动力联合治疗,在动物体内表现出优异的肿瘤细胞生长抑制作用,且无毒副作用.进一步研究表明卟啉与石墨炔之间的高效电子转移使得共轭连接的GDY–TPP的光热/光动力联合治疗效果要优于非共轭连接的GDYO–TPP,实现了通过控制石墨炔中功能基团的键合方式对其光热/光动力联合治疗效果的调控,为设计新型功能石墨炔和光热/光动力联合治疗肿瘤提供了新思路.

In this study, we designed and synthesized two novel porphyrin-modified graphdiyne derivatives(GDYO–TPP and GDY–TPP), which have good dispersity in organic solvents and water and exhibit favourable biocompatibility.It was found that the GDYO–TPP and GDY–TPP not only have excellent photothermal conversion performances, but also have outstanding singlet oxygen generation ability, and can be used for photothermal/photodynamic combination therapy of tumors, showing tremendous inhibition of tumor growth in animals, without side effects. Further studies showed that the efficient electron transfer between porphyrin and graphdiyne made the photothermal/photodynamic combination therapy effect of conjugated GDY–TPP much better than that of non-conjugated GDYO–TPP, which realized the regulation of the photothermal/photodynamic combination therapy by controlling the bonding mode of functional groups. The results provide new ways for designing novel functional graphdiyne and photothermal/photodynamic combination therapy of tumors.