摘要
虹膜角膜内皮(ICE)综合征是一组眼科疾病的总称,包含Chandler综合征(CS)、虹膜色素痣综合征(CRS)和进行性或实质性虹膜萎缩(PIA/EIA)三个亚型,以角膜内皮细胞异常增殖并向虹膜表面迁移为特点,病情缓慢进展且不可治愈。关于本病,目前认为可能的病因是病毒感染,异常内皮膜的形成与收缩则是目前广泛认可的病生理过程。本文中笔者就此病病因与病生理机制的研究现状进行综述。
Iris corneal endothelial(ICE)syndrome is the general name of a group of ophthalmic diseases,including Chandler syndrome(CS),iris nevus syndrome(CRS)and progressive or substantial iris atrophy(PIA/EIA).ICE characterized by abnormal proliferation of corneal endothelial cells and migration to the iris surface.ICE progresses slowly and is incurable.It has been demonstrated that the possible etiology of ICE has been related with viral infection,and the formation and contraction of abnormal endothelial membrane has a widely recognized pathophysiological process.In this paper,the research status of the etiology and pathophysiological mechanism of ICE were reviewed.
作者
张嘉昕
洪晶
Jiaxin Zhang;Jing Hong(Eight-year program 2016,Peking University 3Hospital,Beijing 100191,China;Ophthalmology Department,Peking University 3Hospital,Beijing 100191,China)
出处
《中华眼科医学杂志(电子版)》
2021年第6期370-374,共5页
Chinese Journal of Ophthalmologic Medicine(Electronic Edition)
基金
国家自然科学基金资助项目(81970768)。