C型肉毒毒素的研究进展

Research progress of Botulinum toxin type C

C型肉毒毒素(botulinum neurotoxin type C,BoNT/C)通常与引起动物的食源性肉毒中毒相关,目前尚未发现人类肉毒中毒的相关病例报道。BoNT/C进入神经元细胞可以裂解突触小体相关蛋白-25(synaptosomal-associated protein of 25000,SNAP-25)和突触融合蛋白(syntaxin)。现对BoNT/C的口服毒性及肠上皮细胞的黏膜免疫;神经节苷脂作为神经毒素进入神经元细胞的双受体转运结合机制,以及对BoNT/C应用于临床靶向治疗神经母细胞瘤的进展作一概述。

Botulinum neurotoxin type C is commonly associated with food-borne botulism in animals, There are few relevent reported cases of botulism in humans;BoNT/C can cleave synaptosome-associated proteins-25(SNAP-25) and synaptic fusion proteins(syntaxin) when it enters into neurons;The oral toxicity of BoNT/C and mucosal immunity of intestinal epithelial cells are reviewed.At the same time, the mechanism of bi-receptor transport, binding of ganglioside into neurons as neurotoxin and the new discovery of BONT/C in clinical targeted treatment of neuroblastoma are introduced.