Kisspeptin在高泌乳素血症诱导的下丘脑-垂体-性腺轴功能受抑中的潜在作用

Potential roles of Kisspeptin in the hyperprolactinemiainduced hypothalamic-pituitary-gonad axis suppression

高泌乳素血症(hyperprolactinemia,HPRL)会导致内分泌功能紊乱,以下丘脑-垂体-性腺轴(hypothalamic-pituitary-gonad axis,HPG轴)功能受抑制为重要表现。迄今为止,HPRL诱导的HPG轴功能受抑机制仍未阐明。Kisspeptin是由KiSS-1基因编码的神经肽家族,被视为GnRH神经元的关键上游调节因子,参与大脑性别分化、青春期启动、性激素的正负反馈调节和能量信号转导等。HPRL可能通过下丘脑KiSS-1神经元实现对HPG轴的调控,即Kisspeptin在HPRL诱导的HPG轴功能受抑中可能起重要的作用。

Hyperprolactinemia(HPRL)can lead to endocrine dysfunction,with the suppression of the hypothalamicpituitary-gonad axis(HPG axis)as an important manifestation.So far,the mechanism of HPRL-induced HPG axis suppression remains unclear.Kisspeptin is a family of neuropeptides encoded by the KiSS-1 gene and regarded as a key upstream regulator of GnRH neurons,involved in sex differentiation in brain,puberty initiation,positive and negative feedback regulation of sex hormone and energetic signal transduction.It's reasonable that HPRL inhibits HPG axis via KiSS-1 neurons,that is,Kisspeptin may play a critical role in HPRL-induced HPG axis suppression.