干预肠道菌群联合序贯治疗对缺血性脑卒中患者神经功能的影响

Effect of Intervention of Intestinal Flora Combined with Sequential Therapy on Neurological Function in Patients with Ischemic Stroke

目的探讨干预肠道菌群联合序贯治疗对缺血性脑卒中患者神经功能的影响。方法选取2020年1月-2021年6月我院收治的200例急性缺血性脑卒中住院患者,按照随机数字表法分为治疗组和对照组,每组100例。对照组采用常规治疗,治疗组在对照组基础上联合酪酸梭菌活菌片治疗,比较两组治疗前及治疗后第7、14、28天神经功能缺损评分(NIHSS)和日常生活能力评分(ADL)、临床疗效、不良反应和治疗14 d后脑梗死灶变化。结果两组治疗后第7、14、28天NIHSS评分和ADL评分均优于治疗前,且治疗组优于对照组,差异有统计学意义(P<0.05);治疗组总有效率和显效率分别为98.00%和94.00%,均高于对照组的86.00%和83.00%,差异有统计学意义(P<0.05)。两组患者均无不良反应发生,且治疗组治疗14 d后脑CT显示脑水肿明显消退,无脑出血发生。结论酪酸梭菌活菌片治疗急性缺血性脑卒中疗效确切,可改善患者神经功能,提高日常生活能力,有效性及安全性良好。

Objective To investigate the effect of intervention of intestinal flora combined with sequential therapy on neurological function in patients with ischemic stroke.Methods A total of 200 patients with acute ischemic stroke admitted to our hospital from January 2020 to June 2021 were randomly divided into treatment group and control group,with 100 cases in each group.The control group was treated with routine treatment,and the treatment group was treated with Clostridium butyricum viable tablets on the basis of the control group.The neurological deficit score(NIHSS)and daily living ability score(ADL),clinical efficacy,adverse reactions and changes of cerebral infarction lesions after 14 days of treatment were compared between the two groups before treatment and 7,14 and 28 days after treatment.Results The NIHSS score and ADL score of the two groups at 7,14 and 28 days after treatment were better than those before treatment,and the treatment group was better than the control group,the difference was statistically significant(P<0.05).The total effective rate and markedly effective rate of the treatment group were 98.00%and 94.00%,respectively,which were higher than 86.%and 83.00%of the control group,and the difference was statistically significant(P<0.05).Two groups of patients had no adverse reactions,and the treatment group 14 days after brain CT showed cerebral edema subsided significantly,no cerebral hemorrhage.Conclusion Clostridium butyricum viable tablet is effective in the treatment of acute ischemic stroke,which can improve neurological deficits and daily living ability of patients,and has application efficacy and safety.