UA联合sFIt-1、LKN-1检测对慢性肾小球肾炎的诊断价值

Diagnostic value of UA combined with sFIt-1 and LKN-1 detection in chronic glomerulonephritis

目的探讨尿酸(UA)联合可溶性Fms样络氨酸激酶-1(sFIt-1)、趋化因子白细胞诱素-1(LKN-1)检测对慢性肾小球肾炎的诊断价值。方法选取2019年9月至2020年9月该院收治的肾小球肾炎患者75例为肾小球肾炎组,进一步分为急性肾小球肾炎组、慢性肾小球肾炎组2个亚组。选取同期体检健康者75例为对照组。检测各组UA、sFIt-1、LKN-1等水平并进行比较,对UA、sFIt-1、LKN-1联合检测的诊断价值及与肾功能、疾病分期的相关性进行分析。结果相比于对照组和急性肾小球肾炎组,慢性肾小球肾炎组血清尿素氮(BUN)、血肌酐(SCr)、24 h尿蛋白定量(24 h Upro)、UA、sFIt-1、LKN-1水平较高(P<0.05)。相比于Ⅰ、Ⅱ期患者,Ⅲ期慢性肾小球肾炎患者血清UA、sFIt-1、LKN-1水平较高(P<0.05)。UA、sFIt-1、LKN-1水平与慢性肾小球肾炎患者BUN、SCr、24 h Upro、疾病分期呈正相关(P<0.05)。与UA、sFIt-1、LKN-1单项检测相比,3项联合检测对慢性肾小球肾炎的诊断价值较高(P<0.05)。结论UA、sFIt-1、LKN-1联合检测对慢性肾小球肾炎患者的诊断具有重要意义。

Objective To investigate the diagnostic value of uric acid(UA)combined with soluble Fms like tyrosine kinase-1(sFIt-1),and chemokine interleukin-1(LKN-1)detection in chronic glomerulonephritis.Methods Seventy-five patients with glomerulonephritis admitted to this hospital from September 2019 to September 2020 were selected as the glomerulonephritis group,and further divided into the two subgroups:acute glomerulonephritis group and chronic glomerulonephritis group.Contemporaneous 75 healthy individuals undergoing physical examination were selected as the control group.The levels of UA,sFIt-1,and LKN-1 etc.were measured and the results were compared among the groups.The diagnostic value of UA,sFIt-1 and LKN-1 combined detection and their correlation with the renal function and disease stage was analyzed.Results The levels of serum BUN,SCr,24 h Upro,UA,sFIt-1 and LKN-1 in the acute glomerulonephritis group and chronic glomerulonephritis group were higher than those in the control group(P<0.05).The levels of serum UA,sFIt-1 and LKN-1 in the patients with stageⅢwere higher than those in the patients with stageⅠorⅡ(P<0.05).The levels of UA,sFIt-1 and LKN-1 in the patients with chronic glomerulonephritis were positively correlated with BUN,SCr,24 h Upro and disease stage(P<0.05).Compared with UA,sFIt-1 and LKN-1 single detection,the 3-item combined detection had higher diagnostic value for chronic glomerulonephritis(P<0.05).Conclusion The combined detection of UA,sFIt-1 and LKN-1 is of great significance for the diagnosis of chronic glomerulonephritis.