牙龈卟啉单胞菌促进心血管疾病的研究进展

Research Progress of Porphyromonas Gingivalis Promoting Cardiovascular Disease

慢性牙周炎和心血管疾病为当今社会两大常见的慢性炎症性疾病,受多种危险因素影响。流行病学调查发现,慢性牙周炎与心血管疾病风险增加密切相关。慢性牙周炎患者龈沟内的牙龈卟啉单胞菌可以通过血液和吞噬细胞介导途径侵入心血管组织,分泌毒力因子。通过引发内毒素血症、内皮功能障碍、氧化应激、泡沫细胞形成与脂质蓄积、血管重塑以及斑块破裂与血栓形成,从而导致严重的心血管终末事件。研究牙龈卟啉单胞菌影响心血管疾病的具体途径与机制为预防和治疗伴慢性牙周炎的心血管疾病提供了新的思路。

Chronic periodontitis and cardiovascular disease are two common chronic inflammatory diseases in today's society,which are affected by a variety of risk factors.Epidemiological investigations found that chronic periodontitis is closely related to increased cardiovascular disease risk.Porphyromonas gingivalis colonized in the gingival sulcus of chronic periodontitis patients could invade cardiovascular tissues through bacteremia and phagocyte-mediated pathways and secrete virulence factors.By triggering endotoxemia,endothelial dysfunction,oxidative stress,foam cell formation and lipid accumulation,vascular remodeling,plaque rupture and thrombosis,it leads to serious cardiovascular end-events.The study on the specific ways that Porphyromonas gingivalis affects cardiovascular disease provides a new method for the prevention and treatment of cardiovascular disease,thereby reducing the burden of disease in society.