拉西地平对冠心病单支病变患者PCI术后心肺运动试验指标的影响

Effect of laxidipine on cardiopulmonary exercise test indexes after PCI in patients with coronary artery disease single vessel lesion

目的观察拉西地平对冠心病单支病变患者PCI术后心肺运动试验指标的影响。方法选取在西安市北方医院住院的冠心病单支病变行PCI手术的98例患者作为研究对象,其中采用硝苯地平缓释片治疗的47例作为对照组,采用拉西地平治疗的51例作为观察组,所有患者使用德国Cortex心肺运动功能测试仪进行心肺运动试验指标检测。结果两组患者在治疗前发作次数、持续时间、疼痛程度得分和心绞痛总得分相比,差异均无统计学意义(P>0.05);治疗后,观察组的发作次数、持续时间、疼痛程度得分和心绞痛总得分都明显优于对照组(P<0.05)。两组患者在治疗前静息心率、静息收缩压、静息舒张压、BMI、FVC、FEV_(1)、FEV_(1)/FVC、运动持续时间相比,差异均无统计学意义(P>0.05);治疗后,两组静息收缩压、静息舒张压相比,差异均无统计学意义(P>0.05);治疗后,观察组的静息心率、BMI、FVC、FEV_(1)、FEV_(1)/FVC均低于对照组(P<0.05),运动持续时间长于对照组(P<0.05)。对照组的不良事件总发生率为29.79%,观察组不良事件总发生率为9.80%,两组差异有统计学意义(χ2=10.073,P<0.05)。结论拉西地平能够明显改善冠心病单支血管病变患者PCI术后的心肺功能各项指标,减轻心绞痛症状,提高患者的持续运动能力。

Objective To observe the effect of laxidipine on the cardiopulmonary exercise test indexes after PCI in the patients with coronary artery disease single vessel lesion.Methods Ninety-eight patients with coronary artery disease single vessel lesion treated by PCI hospitalized in this hospital were selected as the research subjects,47 cases treated by nifedipine sustained-release tablets served as the control group,and 51 cases treated by lasidipine served as the observation group.All patients use the German Cortex cardiopulmonary motor function tester for conducting the cardiopulmonary exercise test index detection.Results There was no statistically significant difference in the attack frequency,duration,pain degree scores and total score of angina pectoris before treatment between the two groups(P>0.05);after treatment,the attack frequency,duration,pain degree and total score of angina pectoris in the observation group were significantly better than those in the control group(P<0.05);there was no statistically significant difference in the resting heart rate,resting systolic blood pressure,resting diastolic blood pressure,BMI,FVC,FEV_(1),FEV_(1)/FVC and exercise duration before treatment between the two groups(P>0.05);after treatment,there was no statistically significant difference in the resting systolic blood pressure and resting diastolic blood pressure between the two groups(P>0.05);the resting heart rate,BMI,FVC,FEV_(1) and FEV_(1)/FVC after treatment in the observation group were lower than those in the control group(P<0.05),the exercise duration was longer than that in the control group(P<0.05);the total incidence rate of adverse reactions in the observation group was 29.79%,which in the control group was 9.80%,and the difference between the two groups was statistically significant(χ^(2)=10.073,P<0.05).Conclusion Lacidipine can significantly improve the indexes of cardiopulmonary function,reduce the symptoms of angina pectoris and improve the continuous exercise ability of the patients with coronary heart disease single vessel lesion.