系统性硬化症合并膀胱软斑病1例报告

A case report of bladder malakoplakia in systemic sclerosis patient

系统性硬化症是一种罕见而复杂的自身免疫病,而软斑病是一种罕见的慢性肉芽肿性炎性病变,系统性硬化症合并膀胱软斑病更罕见。本文报道1例系统性硬化症合并膀胱软斑病,患者为中年女性,以血尿和膀胱刺激征为主要临床表现,合并严重腹泻,行经尿道膀胱肿物电切术,术后病理证实为膀胱软斑病。术后服用小剂量泼尼松龙和甲氨蝶呤治疗系统性硬化症。随访6个月,行经尿道膀胱镜检查2次,未见复发。

Systemic sclerosis is a rare and complex autoimmune disease,and malakoplakia is a rare chronic granulomatous inflammatory disease.Systemic sclerosis combined with malakoplakia is extremely rare.Diagnosis is difficult before surgery.It is easy to misdiagnose bladder malakoplakia as bladder tumor.This paper reports a middle-aged female patient with systemic sclerosis complicated with bladder malakoplakia.The main clinical manifestations were hematuria and bladder irritation,accompanied by severe diarrhea.Transurethral resection of bladder tumor was performed.Postoperative pathology proved that it was bladder malakoplakia.After the surgery,she continued to take low-dose prednisolone and methotrexate in the treatment of systemic sclerosis.The patient was followed up for 6 months.Transurethral cystoscopy was performed twice,and there was no recurrence.