新疆新型冠状病毒肺炎患者血型分布特点的分析

Blood Group Distribution Characteristics of COVID-19 Patients in Xinjiang

目的:对新型冠状病毒肺炎(COVID-19)患者ABO、Rh(D)血型分布及相关指标进行分析归纳总结,了解新疆地区新冠肺炎患者血型分布情况及与病程相关性。方法:选取新疆维吾尔自治区新冠肺炎医疗救治定点医院2020年7-8月收住入院的新型冠状病毒肺炎确诊及无症状感染患者共计831例与同期本地区某三甲医院健康体检人群2 778人作对照研究,进行ABO及Rh(D)血型抗原鉴定,并收集相关病历资料进行统计分析。结果:研究组O型人群及Rh(D)阳性人群占比为24.79%及96.27%,较正常对照组29.73%及97.73%低(P<0.05),而AB型和Rh(D)阴性人群为14.20%及3.73%,较正常对照组10.62%及2.27%高(P<0.05),O型人群女性患病者较正常对照组占比低,AB型女性患病组占比较对照组高(P<0.01),O型患病组在≤45岁及>60岁年龄组中占比低,维吾尔族不同血型人群在不同性别中也有自己的特点,但因样本量有限并无统计学意义(P>0.05),而新冠患者病程以及临床诊断分型在不同血型中有差异(P<0.05)。结论:本研究发现,新疆地区新冠肺炎患者的血型分布有自己的特点,并且血型与COVID-19病程及临床诊断分型有关,今后可进一步对多民族不同地区的人群广泛纳入数据完善相关研究。

Objective:To analyze and summarize ABO and Rh(D) blood group distribution and related indicators of COVID-19 patients,and understand the relationship between blood group and disease course of COVID-19 patients in Xinjiang.Methods:A total of 831 patients with confirmed or asymptomatic COVID-19 infection treated in People’s Hospital of Xinjiang Uygur Autonomous Region from July 2020 to August 2020 were enrolled as study group,and 2 778 healthy people in a third Grade A hospital in the region during the same period were selected as control group.ABO and Rh(D) blood group antigens were identified,and relevant medical data were collected for statistical analysis.Results:The proportion of O-type population and Rh(D) positive population in the study group was 24.79% and 96.27%,which were lower than those in the normal control group(29.73% and 97.73%)(P<0.05).The proportion of AB type and Rh(D)negative population was 14.20% and 3.73%,which was higher than that in control group(10.62% and 2.27%)(P<0.05).The proportion of female patients in Type O group was lower than that in control group.The proportion of female patients in AB group was higher than that in control group(P<0.01),while the proportion of type O patients in the age group less than or equal to 45 years old and greater than 60 years old was lower.Different blood groups of Uygur population showed their own characteristics in different sex,but there was no statistical significance due to the limited sample(P>0.05).Moreover,the course of disease and clinical diagnosis of COVID-19 patients were different among different blood groups(P<0.05).Conclusion:This study found that the blood type distribution of COVID-19 patients in Xinjiang has its own characteristics,and the blood type is related to the course and clinical diagnosis of COVID-19.In the future,the data can be widely included in people from different ethnic groups and different regions to improve relevant studies.