儿童感染肺炎克雷伯杆菌的临床特点

目的探讨儿童感染肺炎克雷伯杆菌的临床特点。方法回顾分析2015年1月1日至2021年1月1日温州医科大学附属萧山医院儿童病房收住的肺炎克雷伯杆菌感染患儿156例,收集患儿的姓名、性别、年龄、临床表现、疾病表现,白细胞(WBC)、超敏C-反应蛋白(hs-CRP)、降钙素原(PCT)、白细胞介素-6(IL-6)、IL-10等血指标检查结果,药敏试验结果、选择的抗菌药物以及预后等资料,进行统计分析。结果儿童感染肺炎克雷伯杆菌最常见的疾病表现为呼吸道感染(84.6%),临床表现以咳嗽最多见(78.8%)。WBC、hs-CRP、PCT、IL-6、IL-10等指标可有不同程度的升高,其中PCT比其他指标有着较好的炎症提示作用。目前肺炎克雷伯杆菌对儿童常用的抗菌药物仍较敏感,合理使用抗菌药物治疗的预后良好,均治愈后出院。结论儿童感染肺炎克雷伯杆菌以幼儿常见,其耐药情况并不严重,但需警惕其敏感率的变化。

Objective To investigate the clinical characteristics of klebsiella pneumoniae infection in children.Methods 156 children with klebsiella pneumoniae infection admitted to the children's Ward of Xiaoshan Hospital affiliated to Wenzhou Medical University from January 1,2015 to January 1,2021 were retrospectively analyzed.Their names,gender,age,clinical manifestations and disease manifestations were collected.White blood cell(WBC),hypersensitive C-reactive protein(hs-CRP),procalcitonin(PCT),interleukin-6(IL-6),IL-10 and other blood indicators,drug sensitivity test results,selected antibiotics and prognosis data were statistically analyzed.Results The most common manifestation of klebsiella pneumoniae infection in children was respiratory tract infection(84.6%),and the most common clinical manifestation was cough(78.8%).WBC,HS-CRP,PCT,IL-6,IL-10 and other indicators can be increased to varying degrees,among which PCT had a better inflammatory warning effect than other indicators.At present,klebsiella pneumoniae was still sensitive to commonly used antibacterials in children.Rational use of antibacterials had a good prognosis,and all patients will be discharged after cure.Conclusion Klebsiella pneumoniae infection is common in children,and its drug resistance is not serious,but it is necessary to pay attention to the change of its sensitivity rate.