超声辅助麦默通乳腺微创旋切术对老年乳腺良性肿瘤患者血清疼痛因子及炎症因子水平的影响

Effect of B-ultrasound Assisted Mammotome Minimally Invasive Breast Resection on Serum Inflammatory and Pain Factors in Elderly Patients with Benign Breast Tumors

【目的】探讨超声辅助麦默通乳腺微创旋切术对老年乳腺良性肿瘤患者血清疼痛因子及炎症因子水平的影响。【方法】回顾性分析济南市妇幼保健院收治的92例老年乳腺良性肿瘤患者的临床资料,根据治疗方法的不同分为观察组(n=47)和对照组(n=45)。对照组行开放手术,观察组行超声辅助麦默通乳腺微创旋切术。对比两组手术情况、并发症、术后肿瘤残留情况,比较两组手术前后血清疼痛因子及炎症因子水平。【结果】观察组手术时间、切口愈合时间、住院时间、瘢痕长度、术中出血量均低于对照组,差异有统计学意义(P<0.05)。术后3d,两组患者血清神经肽Y(NPY)、5-羟色胺(5-HT)、前列腺素E2(PGE2)水平均高于术前,但观察组低于对照组,差异有统计学意义(P<0.05);两组患者血清白细胞介素-10(IL-10)、C反应蛋白(CRP)水平较术前增高,观察组低于对照组,两组患者干扰素-γ(INF-γ)水平低于术前,观察组高于对照组(P<0.05)。观察组术后肿瘤残留2例(4.26%),低于对照组的3例(6.67%),差异无统计学意义(P>0.05)。观察组并发症发生率为6.38%(3/47),低于对照组的22.22%(10/45),差异有统计学意义(P<0.05)。【结论】超声辅助麦默通乳腺微创旋切术治疗老年乳腺良性肿瘤具有手术时间短、瘢痕小、疼痛程度轻、术后恢复快、创伤小、并发症少等优势,且能减轻机体炎症反应,值得临床推荐。

【Objective】To explore the effect of B-ultrasound assisted Mammotome minimally invasive breast resection on postoperative recovery and serum pain factors,expression in elderly patients with benign breast tumors.【Methods】The clinical data of 92 elderly patients with benign breast tumors in Jinan Maternal and Child Care Hospital were selected for retrospective analysis.They were divided into the observation group(n=47)and the control group(n=45)according to different treatment methods.The control group underwent open surgery,while the observation group underwent B-ultrasound assisted Mammotome minimally invasive breast resection.The surgical status,complications,postoperative tumor residual status,treatment satisfaction,and incision aesthetic score,serum pain factors and immune function indexes before operation and after operation were compared between the two groups.【Results】The operation time,incision healing time,hospitalization time and scar length in the observation group were shorter than those in the control group,and the intraoperative blood loss was lower than that of the control group(P<0.05).Serum levels of NPY,5-HT,PGE2,IL-10,and CRP in the two groups before surgery were higher than those on the 3rd day after surgery,but the observation group was lower than the control group and the difference was statistically significant(P<0.05).The levels of serum IL-10 and CRP in the two groups were higher than those before operation,and the observation group was lower than the control group.The levels of INF-γin the two groups were lower than those before operation,and the observation group was higher than the control group(P<0.05).There were 2 cases(4.26%)of residual tumor in the observation group,which was lower than 3 cases(6.67%)in the control group,and the difference was not statistically significant(P>0.05).The incidence of complications in the observation group was 6.38%(3/47),which was lower than 22.22%(10/45)in the control group,and the difference was statistically significant(P<0.05).【Conclusion】The use of B-ultrasound assisted Mammotome minimally invasive breast resection for the treatment of the elderly patients with benign breast tumors has the advantages of short operation time,small scars,light pain,quick postoperative recovery,less trauma,fewer complications,high incision aesthetics and better patient satisfaction.Also it can reduce the body's inflammatory response and immunosuppressive state,which provides significant curative effect and fewer complications.