消化性溃疡患儿Hp感染与hBD-2、PGⅠ/PGⅡ、Th1/Th2水平的相关性及影响因素分析

Correlation and Influencing Factors between Hp Infection and hBD-2,PGⅠ/PGⅡand Th1/Th2 Levels in Children with Peptic Ulcer

【目的】探讨消化性溃疡(PU)患儿幽门螺杆菌(Hp)感染与人β2防御素2(hBD-2)、胃蛋白酶(PG)Ⅰ/PGⅡ、辅助性T淋巴细胞(Th)1/Th2水平的相关性及影响因素。【方法】选取本院收治的84例PU患儿,根据Hp感染情况分为Hp阳性组(n=31)与Hp阴性组(n=53),比较两组基线资料、炎症评分、hBD-2、PGⅠ/PGⅡ、Th1/Th2水平,分析hBD-2、PGⅠ/PGⅡ、Th1/Th2与炎症评分及Hp感染的相关性,探讨PU患儿HP感染的影响因素。【结果】Hp阳性组hBD-2、PGⅠ/PGⅡ、炎症评分高于Hp阴性组,Th1/Th2低于Hp阴性组(P<0.05)。hBD-2、PGⅠ/PGⅡ与Hp阳性患儿炎症评分均呈正相关性,Th1/Th2与Hp阳性患儿炎症评分呈负相关性(P<0.05);hBD-2、PGⅠ/PGⅡ与Hp感染均呈正相关性,Th1/Th2与Hp感染呈负相关性(P<0.05)。照顾者胃肠道疾病史、个人卫生良好、分餐情况、吸吮手指、hBD-2、PGⅠ/PGⅡ、Th1/Th2均为PU患儿Hp感染影响因素(P<0.05)。【结论】PU患儿Hp感染与hBD-2、PGⅠ/PGⅡ、Th1/Th2水平失衡密切相关,且与个人卫生、照顾者胃肠道疾病史等有关。

【Objective】To investigate the relationship between Helicobacter pylori(HP)infection with hBD-2,PGⅠ/PGⅡand Th 1/Th2 levels in children with peptic ulcer(PU),and its influencing factors.【Methods】A total of 84 children with PU treated in our hospital was divided into HP positive group(n=31)and HP negative group(n=53)according to the situation of HP infection.The baseline data,inflammatory score,hBD-2,PGⅠ/PGⅡand Th1/Th2 levels of the two groups were compared.The correlation between hBD-2,PGⅠ/PGⅡand Th1/Th2 and inflammatory score and HP infection was analyzed to explore the influencing factors of HP infection in children with PU.【Results】The scores of hBD-2,PGⅠ/PGⅡand inflammation in the HP positive group were higher than those in the HP negative group,and Th1/Th2 were lower than those in the HP negative group(P<0.05).HBD-2,PGⅠ/PGⅡwere positively correlated with the inflammatory score of HP positive children,and Th1/Th2 was negatively correlated with the inflammatory score of HP positive children(P<0.05);HBD-2,PGⅠ/PGⅡwere positively correlated with HP infection,and Th1/Th2 was negatively correlated with HP infection(P<0.05).The history of gastrointestinal diseases,good personal hygiene,meal sharing,finger sucking,hBD-2,PGⅠ/PGⅡand Th1/Th2 were the influencing factors of HP infection in children with PU(P<0.05).【Conclusion】HP infection in children with PU is closely related to the imbalance of hBD-2,PGⅠ/PGⅡand Th1/Th2 levels,as well as personal hygiene and the history of gastrointestinal diseases of caregivers.