染色体外环状DNA的研究进展

Research Advances on Extrachromosomal Circular DNA

染色体外环状DNA(extrachromosomal circular DNA,eccDNA)是存在于真核生物染色体外的环状DNA分子,由基因组中的DNA或细胞内的外源DNA形成。eccDNA是一类特殊的遗传物质,可以携带完整的基因,编码有功能的蛋白质或RNA。研究表明,eccDNA可以通过特殊的方式参与多种生理和病理过程,例如:衰老、肿瘤的发生等。该文综述了eccDNA的最新研究进展,并对eccDNA与肿瘤的关系进行深入的阐述。

eccDNA(extrachromosomal circular DNA)is a kind of circular DNA molecule in eukaryotes.It is a kind of special genetic material and carry complete genes which can express functional protein or RNA.eccDNA can be generated by DNA from endogenous genome and exogenous DNA in cells.Several studies have proved eccDNA can participate in various physiological and pathological processes,such as aging and tumorigenesis.In this paper,the authors review the research progress of eccDNA and elaborate the relationship between eccDNA and tumor.