线性泛素化研究进展

Research Progress of Linear Ubiquitination

线性泛素化是一种新型泛素化修饰方式,不同于赖氨酸介导的多聚泛素化,其主要通过泛素分子的首尾相连对蛋白质进行翻译后修饰,以线性泛素化复合体(LUBAC)作为E3连接酶,参与细胞的抗凋亡、抗病毒作用,以及炎症反应等细胞生命活动。该文主要介绍了线性泛素化的组成、对蛋白质进行修饰的主要方式,其参与调控的体内生理活动信号通路,并讨论了其在肿瘤、自身免疫病等发生发展过程中所起到的表观遗传学调控作用。

Linear ubiquitination is a new kind of ubiquitin modification.Compared with the polyubiquitination mediated by lysine,linear ubiquitination mainly involves head-to-tail connection between ubiquitin molecules.Linear ubiquitination is mediated by LUBAC(linear ubiquitination complex),an E3 ligase,which participates in myriad cellular activities including anti-apoptosis,antiviral effect,and inflammation of cells.This review mainly introduces the composition and the modification ways of linear ubiquitination,the signaling pathways that linear ubiquitination has participated in,and its epigenetic regulatory roles in pathogenesis of diseases such as tumors,autoimmune diseases,etc.