SREBP2表达及活性调控的研究进展

Research Progress on Expression and Activity Regulation of SREBP2

胆固醇稳态对细胞功能和机体健康至关重要,胆固醇调节元件结合蛋白2(sterol-regulatory element binding protein 2,SREBP2)是维持胆固醇稳态的关键调控因子,是一种位于细胞内质网的胆固醇敏感调节器。SREBP2的表达和功能主要受三个水平的调控:(1)SREBF2基因的转录调控,(2)SREBP2蛋白的转运与剪切调控,(3)nSREBP2的修饰及功能调控。该文系统地对上述三个阶段调控的研究进展及其在代谢性疾病中的作用进行了综述,这将为靶向SREBP2研究胆固醇代谢及其代谢异常相关疾病的治疗提供理论参考。

Cholesterol homeostasis is very important to cells and organisms.REBP2(sterol-regulatory element binding protein 2)is a key regulator of cholesterol homeostasis located in the endoplasmic reticulum to sense cholesterol changes.The expression and functions of SREBP2 are mainly regulated at three levels:(1)transcriptional regulation of SREBF2 gene,(2)transport and splicing regulation of SREBP2 protein,and(3)modification and functional regulation of nSREBP2.This study summerizes the research progress of the above three stages of regulation and their role in metabolic diseases,which will provide a theoretical reference for targeting SREBP2 to study cholesterol metabolism and the treatment of diseases related to abnormal metabolism.