RTS,S/AS01疟疾疫苗大规模现场应用可能面临的挑战

Potential challenges for large-scale uses of RTS,S/AS01 vaccine in malaria-endemic areas

RTS,S/AS01疟疾疫苗获得WHO批准大规模应用是人类抗击寄生虫感染史上的一个里程碑,然而RTS,S/AS01疫苗并非完美。本文从免疫学角度探讨了RTS,S/AS01疟疾疫苗存在的不足以及下一代疟疾疫苗研发可能面临的挑战。

RTS,S/AS01 vaccine has recently been recommended by the WHO for large-scale uses in malaria-endemic areas,which is a milestone in the history of the fight against parasitic infections.Nevertheless,RTS,S/AS01 vaccine is not perfect.Hereby,the shortages of RTS,S/AS01 malaria vaccine were discussed,and the potential challenges during the research and development of next-generation malaria vaccines were analyzed.