格列吡嗪与瑞格列奈治疗2型糖尿病的效果比较

Comparison of efficacy of glipizide versus repaglinide in the treatment of type 2 diabetes mellitus

目的比较格列吡嗪与瑞格列奈治疗2型糖尿病的临床疗效。方法抽取朔州市中心医院2018年1月至2019年12月收治的108例2型糖尿病患者为研究对象,采用随机数字表法分为两组,每组54例。对照组采用格列吡嗪治疗,观察组采用瑞格列奈治疗。治疗6个月后评价两组疗效,比较两组治疗前后血糖指标、血脂指标、治疗效果及不良反应发生情况。结果治疗前,两组血糖指标、血脂指标水平比较差异未见统计学意义(P>0.05);治疗后,观察组血糖指标、血脂指标水平改善情况优于对照组(P<0.05)。观察组总有效率(98.15%,53/54)高于对照组(85.18%,46/54),差异有统计学意义(P<0.05)。两组不良反应发生率比较差异未见统计学意义(P>0.05)。结论与格列吡嗪方案相比,瑞格列奈方案治疗2型糖尿病可更好地改善患者的血糖指标与血脂指标,疗效更好且不良反应少。

Objective To compare the clinical effects of glipizide and repaglinide on type 2 diabetes mellitus.Methods A total of 108 patients with type 2 diabetes mellitus admitted to Shuozhou Central Hospital from January 2018 to December 2019 were randomly divided into two groups,with 54 cases in each group.The control group was treated with glipizide,and the observation group was treated with repaglinide.After 6 months of treatment,the therapeutic effects of the two groups were evaluated,and blood glucose,lipid indexes,efficacy and adverse effects were compared between the two groups before and after treatment.Results Before treatment,there was no difference in blood glucose indexes or lipid indexes between the two groups(P>0.05).After treatment,the observation group had better improvement in blood glucose indexes and lipid indexes than the control group(P<0.05).The total effective rate of the observation group(98.15%,53/54)was higher than that of the control group(85.18%,46/54),P<0.05.There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions Compared with glipizide,repaglinide can better improve the blood glucose and lipid indexes,and has better curative effects and fewer adverse reactions in the treatment of type 2 diabetes mellitus.