维生素E联合氯米芬治疗成年特发性少精弱精症的临床效果

Effect of vitamin E combined with clomiphene on adult patients with idiopathic oligospermia and asthenospermia

目的探讨维生素E联合氯米芬治疗成年特发性少精弱精症患者的效果。方法抽取酒泉市人民医院2019年1月至2021年1月收治的采用氯米芬治疗的成年特发性少精弱精症患者100例,纳入对照组;另抽取同期采用维生素E联合氯米芬治疗的成年特发性少精弱精症患者100例,纳入观察组。比较两组治疗前、治疗3个月结束时精子活性(精子浓度、精子总活动率、精子向前活动率)、性激素[睾丸素(Ts)、促卵泡生成素(FSH)、黄体生成素(LH)]水平,并统计比较两组治疗期间的不良反应发生情况。结果治疗3个月结束时,两组精子浓度、精子总活动率、精子向前活动率均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);治疗3个月结束时,两组LH、FSH、Ts水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);治疗期间,对照组不良反应发生率为10.00%(10/100),观察组为12.00%(12/100),两组比较差异未见统计学意义(P>0.05)。结论维生素E联合氯米芬治疗成年特发性少精弱精症患者效果显著,可有效提高患者的精子活性,促进性激素分泌,且不增加不良反应。

Objective To investigate the effect of vitamin E combined with clomiphene on adult patients with idiopathic oligospermia and asthenospermia.Methods A total of 100 adult patients with idiopathic oligozoospermia and asthenospermia treated with clomiphene in Jiuquan People’s Hospital from January 2019 to January 2021 were selected and included in the control group;another 100 adult patients with idiopathic oligozoospermia and asthenospermia treated with vitamin E combined with clomiphene in the same period were selected and included in the observation group.The levels of sperm activity(sperm concentration,total sperm activity rate,forward sperm activity rate),sex hormones,including testosterone(Ts),follicle-stimulating hormone(FSH),luteinizing hormone(LH),before treatment and at the end of 3 months of treatment were compared between the two groups.And the adverse reactions of the two groups during treatment were compared.Results At the end of 3 months of treatment,the sperm concentration,total sperm activity rate and forward sperm activity rate of the two groups were higher than those before treatment,and the above indexes in the observation group were higher than those in the control group(P<0.05).At the end of 3-month treatment,the levels of LH,FSH and Ts in the two groups were higher than those before treatment,and those in the observation group were higher than those in the control group(P<0.05).During the treatment,the incidence of adverse reactions was 10.00%(10/100)in the control group,and 12.00%(12/100)in the observation group,however,there was no significant difference between the two groups(P>0.05).Conclusions Vitamin E combined with clomiphene has a significant effect in the treatment of adult idiopathic oligozoospermia and asthenospermia,which can effectively improve the sperm activity and promote the secretion of sex hormones,without increasing adverse reactions.