摘要
肠道内数量庞大的菌群对宿主的生理病理功能有着不可忽视的影响.研究显示肠道菌群能够通过合成和释放一些重要的神经递质及调节因子来影响中枢神经系统的功能,肠道菌群的紊乱与血脑屏障完整性降低有关.肠道菌群的稳态在预防与治疗神经退行性疾病中有重要意义.本文拟综述血脑屏障完整性与菌-肠-脑轴相关性的最新进展,为从肠道出发治疗神经系统疾病提供新的方向.
A wide variety of gut microbes has a non-negligible physiological and pathological impact on the host.Studies show that gut microbes can influence the function of the central nervous system by synthesizing and releasing several key neurotransmitters and neuroregulatory factors.Decreasing the integrity of the blood-brain barrier is related to the disorder of gut microbes,and maintaining the homeostasis of gut microbes is of great significance in preventing and treating neurodegenerative diseases.This review summarizes the possible mechanism of the intestine flora-gut-brain axis as a signaling pathway and presents several ideas and potential directions for regulating gut microbes to achieve the purpose of disease treatment.
作者
华嵘暄
高晗
王博雅
郭玥昕
梁宸
高磊
尚宏伟
徐敬东
Rong-Xuan Hua;Han Gao;Bo-Ya Wang;Yue-Xin Guo;Chen Liang;Lei Gao;Hong-Wei Shang;Jing-Dong Xu(Clinical Medicine“5+3”Program,Capital Medical University,Beijing 100069,China;Department of Physiology and Pathophysiology,School of Basic Medical Sciences,Capital Medical University,Beijing 100069,China;Clinical Medicine Program,Peking University Health Science Center,Beijing 100081,China;Oral Medicine“5+3”Program,Capital Medical University,Beijing 100069,China;Clinical Medicine,Capital Medical University,Beijing 100069,China;Department of Biomedical Informatics,School of Biomedical Engineering,Capital Medical University,Beijing 100069,China;Morphological Experiment Center,School of Basic Medical Sciences,Capital Medical University,Beijing 100069,China)
出处
《世界华人消化杂志》
CAS
2022年第2期100-108,共9页
World Chinese Journal of Digestology
基金
国家自然科学基金资助项目,No.82174056和No.81673671
国家重点研发计划“重大慢性非传染性疾病防控研究”重点专项课题,No.2016YFC1306305.
关键词
菌-肠-脑轴
血脑屏障
神经退行性疾病
肠道微生物
粘膜屏障
阿尔兹海默
Intestine flora-gut-brain axis
Blood-brain barrier
Neurodegeneration disease
Gastrointestinal microbiome
Mucosal barrier
Alzheimer’s disease
