肾阳亏虚证泄泻的现代生物学内涵

Modern biological connotation of diarrhea with kidney-Yang deficiency syndrome

肾阳亏虚证作为泄泻常见中医证型,其发病机制较为复杂.本文从肠道菌群、信号通路、“肾-肠轴”相关分子三个层面探究肾阳亏虚证泄泻发生发展的作用机制,寻找肾阳亏虚证泄泻的生物标记物,对揭示肾阳亏虚证泄泻的现代生物学内涵以及推进后续临床的靶向治疗具有重要意义.

Kidney-Yang deficiency syndrome,a common traditional Chinese medicine syndrome of diarrhea,has a complex pathogenesis.This paper explores the mechanisms of the development of diarrhea with kidney-Yang deficiency syndrome from three aspects:Gut flora,signaling pathway,and molecules related to the“kidney-gut axis”,and tries to identify biomarkers for diarrhea with kidney-Yang deficiency syndrome.It is of great significance to reveal the modern biological connotation of diarrhea with kidney-Yang deficiency syndrome,which can promote the subsequent clinical targeted therapy.