阿托伐他汀联合银杏叶提取物对颅内动脉狭窄患者认知功能及血清解偶联蛋白2、脑源性神经营养因子水平的影响

Effect of Atorvastatin combined with Ginkgo Biloba extract on cognitive function and serum uncoupling protein 2 and brain-derived neurotrophic factor levels in patients with intracranial artery stenosis

目的探讨阿托伐他汀联合银杏叶提取物在颅内动脉狭窄患者中的应用价值。方法选取2019年3月至2021年3月保定市第二医院收治的112例颅内动脉狭窄患者作为研究对象,采用随机数字表法将其分为对照组与研究组,每组各56例。对照组患者采用阿托伐他汀治疗,研究组患者采用阿托伐他汀+银杏叶提取物治疗,均持续用药3个月。比较两组患者的认知功能、日常生活活动能力、血清解偶联蛋白2(UCP2)、脑源性神经营养因子(BDNF)、血脂水平及不良反应发生情况。结果治疗前,两组患者的简易智能精神状态检查量表(MMSE)、日常生活活动能力量表(ADL)评分及UCP2、BDNF、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平比较,差异无统计学意义(P>0.05);治疗后,研究组患者的MMSE、ADL评分及UCP2、BDNF、HDL-C水平高于对照组,TC、TG、LDL-C水平低于对照组,差异有统计学意义(P<0.05)。两组患者的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论阿托伐他汀联合银杏叶提取物能够改善颅内动脉狭窄患者的血脂及血清UCP2、BDNF水平,促进患者认知功能及日常生活活动能力恢复,安全可靠。

Objective To explore the application value of Atorvastatin combined with Ginkgo Biloba extract in patients with intracranial artery stenosis.Methods A total of 112 patients with intracranial artery stenosis admitted to the Second Hospital of Baoding City from March 2019 to March 2021 were divided into the control group and the study group by random number table method,with 56 cases in each group.Patients in the control group were treated with Atorvastatin,and patients in the study group were treated with Atorvastatin and Ginkgo Biloba extract,both of which were treated continuously for three months.The cognitive function,activities of daily living,serum uncoupling protein 2(UCP2),brain-derived neurotrophic factor(BDNF),blood lipid levels and adverse reactions were compared between the two groups.Results Before treatment,there were no the statistically significant differences in scores of the mini mental state examination scale(MMSE),the activity of daily living ability scale(ADL),levels of UCP2,BDNF,total cholesterol(TC),triglycerides(TG),high-density lipoprotein cholesterol(HDL-C)and low-density lipoprotein cholesterol(LDL-C)between the two groups(P>0.05).After treatment,MMSE,ADL scores and UCP2,BDNF,HDL-C levels of the study group were higher than those in the control group,the levels of TC,TG and LDL-C of the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Atorvastatin combined with Ginkgo Biloba extract can improve blood lipids,serum UCP2 and BDNF levels in patients with intracranial artery stenosis,and promote the recovery of cognitive function and activities of daily living,which is safe and reliable.