活血清热解毒法辅助治疗糖尿病足的临床疗效观察

Clinical observation of Huoxue Qingre Jiedu method in the treatment of diabetic foot

目的分析活血清热解毒法辅助治疗糖尿病足的临床效果。方法选取2020年9月至2021年10月江西省赣州市中医院接诊的50例糖尿病足患者作为研究对象,采用随机数字表法将其分为对照组和观察组,每组各25例。对照组患者实施基础治疗,观察组患者实施基础治疗和活血清热解毒法辅助治疗。比较两组患者的治疗有效率、溃疡面积、足背动脉血流速度、血液流变学以及炎症因子水平。结果观察组患者的治疗有效率为96.00%,高于对照组的64.00%(P<0.05)。两组患者治疗前的溃疡面积及足背动脉血流速度比较,差异无统计学意义(P>0.05)。观察组患者治疗后的溃疡面积小于对照组,足背动脉血流速度高于对照组(P<0.05)。两组患者治疗前的全血黏度(高切)、血浆黏度、纤维蛋白原、糖化血红蛋白水平比较,差异无统计学意义(P>0.05)。观察组患者治疗后的全血黏度(高切)、血浆黏度、纤维蛋白原水平低于对照组(P<0.05)。两组患者治疗后的糖化血红蛋白水平比较,差异无统计学意义(P>0.05)。两组患者治疗前的C-反应蛋白(CRP)、降钙素原(PCT)及D-二聚体(D-D)水平比较,差异无统计学意义(P>0.05)。观察组患者治疗后的CRP、PCT及D-D水平低于对照组(P<0.05)。结论活血清热解毒法辅助治疗糖尿病足的效果较好,可减轻患者的疮面感染程度、加速愈合,改善血液流变,降低血液黏滞度,值得临床应用推广。

Objective To analyze the clinical effect of Huoxue Qingre Jiedu method in the treatment of diabetic foot.Methods A total of 50 patients with diabetic foot admitted in Ganzhou Hospital of Traditional Chinese Medicine in Jiangxi Province from September 2020 to October 2021 were selected as subjects.They were divided into control group and observation group by random number table method,with 25 cases in each group.The control group received basic treatment,and the observation group received basic treatment and Huoxue Qingre Jiedu method.The treatment efficiency,ulcer area,blood flow velocity of dorsalis pedis artery,hemorheology and inflammatory factor levels were compared between the two groups.Results The effective rate of observation group was 96.00%,which was higher than that of control group(64.00%)(P<0.05).There were no significant differences in ulcer area and blood flow velocity of dorsal foot artery between the two groups before treatment(P>0.05).After treatment,the ulcer area in observation group was smaller than that in control group,and the blood flow velocity of dorsal foot artery was higher than that in control group(P<0.05).There were no significant differences in whole blood viscosity(hypercut),plasma viscosity,fibrinogen and glycosylated hemoglobin levels between the two groups before treatment(P>0.05).After treatment,whole blood viscosity(hypercut),plasma viscosity and fibrinogen levels in observation group were lower than those in control group(P<0.05).There was no significant difference in glycosylated hemoglobin level between the two groups after treatment(P>0.05).There were no significant differences in the levels of C-reactive protein(CRP),procalcitonin(PCT)and D-dimer(D-D)between the two groups before treatment(P>0.05).The CRP,PCT and D-D levels in observation group were lower than those in control group after treatment(P<0.05).Conclusion The effect of Huoxue Qingre Jiedu method in the auxiliary treatment of diabetic foot is good,which can reduce the degree of wound infection,accelerate healing,improve blood rheology and reduce blood viscosity,which is worthy of clinical application and promotion.