缩醛/缩酮的合成研究进展

Research Progress in Synthesis of Acetal/Ketal

醛/酮与醇或原甲酸酯进行亲核加成反应生成的产物缩醛/缩酮,是一类重要的有机化合物。在有机合成中,该反应也广泛用于醛/酮羰基的保护或者乙二醇的保护,因此,缩醛/缩酮的合成研究引起广泛的关注。本文根据反应体系的不同,从酸催化、电催化和光催化三个方面对近年来缩醛/缩酮的合成研究进展进行详细综述。期望该综述作为学生基础有机化学课程的课后拓展阅读内容,能加深学生对基础反应的理解,培养学生的科研创新思维。

Acetal/ketal is a kind of important organic compounds, which is prepared by the nucleophilic addition reaction of aldehyde/ketone with alcohol or orthoformate. This reaction is also widely applied for protection of carbonyl group of aldehyde/ketone or ethylene glycol in organic synthesis. Therefore, synthesis of acetal/ketal attracts extensive concern. According to the different reaction systems, the research progress of acetal/ketal synthesis in recent years was reviewed in detail from three aspects, including acid catalysis, electrocatalysis and photocatalysis. It is expected that students could master this basic reactions and students’ innovation ability will be developed by this review.