鼻三针联合穴位贴敷治疗肺虚感寒型变应性鼻炎的临床研究

Clinical Study of Bi San Zhen Combined with Acupoint Sticking for Allergic Rhinitis of Lung Deficiency and Cold Contraction Pattern

目的采用多中心随机对照研究观察鼻三针联合穴位贴敷治疗肺虚感寒型变应性鼻炎的临床疗效。方法将160例符合纳入标准的肺虚感寒型变应性鼻炎患者随机分为两组(治疗组79例,对照组81例)。治疗组用鼻三针联合穴位贴敷进行治疗,对照组采用安慰治疗。比较两组患者治疗前、治疗2周后、治疗后、治疗后4周、治疗后8周以及治疗后12周的鼻症状总评分(TNSS)和鼻炎患者生活质量问卷(RQLQ)评分。结果治疗前两组TNSS和RQLQ评分比较,差异无统计学意义(P>0.05)。与治疗前比较,治疗组治疗2周后、治疗后、治疗后4周、治疗后8周和治疗后12周的TNSS和RQLQ评分均有所改善(P<0.05);且上述各时间点,治疗组TNSS和RQLQ评分均优于对照组(P<0.05)。TNSS评分中,时间因素以及时间因素和分组的交互作用具有统计学意义(P<0.05)。结论鼻三针联合穴位贴敷治疗肺虚感寒型变应性鼻炎可显著改善患者鼻症状和生活质量,且对改善鼻部症状的效应比较持久。

Objective To observe the clinical efficacy of Bi San Zhen(acupuncture at three acupoints particularly for nasal conditions)plus acupoint sticking therapy in treating allergic rhinitis of lung deficiency and cold contraction pattern via a multi-center randomized controlled design.Method A total of 160 eligible patients with allergic rhinitis due to lung deficiency and cold contraction were randomized into two groups(79 cases in the treatment group and 81 cases in the control group).The treatment group was intervened by Bi San Zhen plus acupoint sticking therapy,and the control group received placebo treatment.The total nasal symptom score(TNSS)and rhinitis quality of life questionnaire(RQLQ)score were compared before the treatment,after 2-week treatment,at the end of the treatment,and 4,8,and 12 weeks after the treatment for the two groups.Result There was no significant difference in the TNSS or RQLQ score between the two groups(P>0.05).Compared with the baseline,the TNSS and RQLQ score showed improvements in the treatment group after 2-week treatment,at the end of the treatment,and 4,8,and 12 weeks after the treatment(P<0.05).In addition,at the time points mentioned above,the treatment group was superior to the control group comparing the TNSS and RQLQ score(P<0.05).Regarding the TNSS,the time factor and the interaction between time and grouping showed notable influences(P<0.05).Conclusion Bi San Zhen plus acupoint sticking can significantly improve the nasal symptoms and quality of life in allergic rhinitis due to lung deficiency and cold contraction,and its effects in improving nasal symptoms are enduring.