基于3D打印技术的血流成像光纤探头设计

Design of Optical Fiber Probe for Blood Flow Imaging Based on 3D Printing

目的使用3D打印技术设计制作一种适合近红外漫射光相关层析成像技术的光纤探头,以获取更精准的组织血流值。方法使用Solidworks软件进行光纤探头的3D建模,根据设计模型,利用光敏树脂材料完成光纤探头的3D打印;并利用3D打印的平板式光学探头在仿体实验和人体实验中进行有效性验证。结果在仿体实验中,使用3D打印技术设计的血流成像探头可以将异质物进行清晰成像和准确定位;在人体实验中,可以准确稳定的获取30例受试者的人体头部组织的血流变化并进行成像。结论使用3D打印技术制作的光纤探头适用于近红外漫射光相关层析成像,可以准确地获取组织血流变化,该探头有望用于脑部多种疾病的临床诊断与治疗评估。

Objective To obtain more accurate blood flow values,a fiber optic probe suitable for near-infrared diffuse correlation tomography(DCT)technology was designed and manufactured based on 3D printing.Methods Solidworks was used for 3D modeling of the fiber optic probe.According to the design model,photosensitive resin material was used to complete the 3D printing of the optical fiber probe.The effectiveness of the 3D printed flat optical probe was verified in simulation experiment and human experiments.Results In the simulation experiment,the blood flow imaging probe designed by using 3D printing technology can clearly image and accurately locate the solid anomaly.In the human experiment,it can accurately and stably obtain the blood of head tissue of 30 cases of subjects,and the flow changes and imaging is performed.Conclusion The optical fiber probe made by 3D printing technology is suitable for near-infrared DCT and can accurately obtain the changes of tissue blood flow.The probe is expected to be used for clinical diagnosis and treatment evaluation of a variety of brain diseases.